Apoptosis lung cancer

These arotinoids, which were first introduced for the treatment of skin diseases, may also have potential as anticancer diugs. For example, the synthetic retinoid 6-[3-(l-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in a variety of cancer cells including lung cancer cells in vitro, and studies concerning the use of this agent in vivo would be desirable. 

Hida T, Kozaki K, Muramatsu H, et al. Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res 2000 6 2006-2011. 

Masuda A, Maeno K, Nakagawa T et al. Association between mitotic spindle checkpoint impairment and susceptibility to the induction of apoptosis by anti-microtubule agents in human lung cancers. Am... 

Radhakrishna Pillai G, Srivastava AS, Hassanein TI, Chauhan DP, Carrier E. 2004. Induction of apoptosis in human lung cancer cells by curcumin. Cancer Lett 208 163-170. 

This SERS labeling approach has been used by Yu and co-workers for imaging apoptosis in cells and lung cancer tissue [32]. In most reported SERS imaging papers, the SERS nanoparticles have been prepared by the investigators themselves. Yu et al. were able to employ the commercially available SERS-active nanoparticles, and so have demonstrated that SERS imaging is now open to a much larger community of scientists than just SERS specialists. 

Paraneoplastic autonomic neuropathy is primarily seen with SCLC [103]. Lymphoma, non-small cell lung cancer, and ovarian cancer are also associated with autonomic disturbances [104]. Autonomic dysfunction affects 23-30% of Hu antibody positive patients [36, 98] and is the predominant symptom at presentation in up to 9% of the patients [90]. The onset of symptoms is usually subacute. A prominent clinical manifestation in patients with paraneoplastic autonomic neuropathy is gastrointestinal dysmotility and intestinal pseudo-obstruction, which can occur as part of the PEM/SN syndrome or as the sole symptom of Hu antibody related PNS. Ortostatic hypotension and erectile dysfunction are other common features [37, 105, 106], Autonomic neuropathy is also commonly associated with the CRMP-5 antibody and have been detected in more than 30% of CRMP-5 antibody positive patients [30], Inflammation in autonomic ganglia and infiltration of B and T cells have been demonstrated at autopsy [107], and Hu antibodies have been shown to induce neuronal apoptosis in cultured myenteric neurons [105],... 

Kawakami, A., Suzuki, S., Yamashita, F., and Hashida, M. (2006), Induction of apoptosis in A549 human lung cancer cells by all-trans retinoic acid incorporated in DOTAP/ cholesterol liposomes, / Controlled Release, 110,514-521. 

Yang L, et al. Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460... 

Recently, 3,4,5-trimethoxy-4 -bromo-cis-stilbene, considered a resveratrol analogue, has been reported to induce G2/M cell cycle arrest and apoptosis in human lung cancer cells [20]. 

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