Apolipoprotein D

Zeng C., Vowels B., Spielman A., Leyden J., et al. (1996). A human axillary odorai carried by Apolipoprotein-D. Proc Natl Acad Sci 93, 6626-6630. 

Hunter SB, Varma V, Shehata B, et al. Apolipoprotein D expression in primary brain tumors analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem. 2005 53 963-969. 

A7. Albers, J. J., Taggart, H, M., Applebaum-Bowden, D., Haffner, S., Chesnut, C. H., Ill, and Hazzard, W. R., Reduction of lecithin-cholesterol acyltransferase, apolipoprotein D and the Lp(a) lipoprotein with the anabolic steroid Stanozolole. Biochim. Biophys. Acta 795, 293-296 (1984). 

Only two short-term prospective studies on the effect of soy on the breast have been performed to date. The first reported the effects of two weeks of soy supplementation on the breast of women who were due to have surgery for either benign or malignant breast disease (Hargreaves, 1999). Soy had no adverse effects on any histological index of proliferation. However, a rise of pS2 protein and lowering of apolipoprotein D was observed in the nipple aspirate of women taking soy compared with controls. (A similar effect has... 

Glockner, E., Ohn, T.G. (2003) Hippocampal apolipoprotein D level depends on Braak stage and APOE genotype. Neuroscience, 122, 103-110. 

ASOB2 is apolipoprotein D (apoD) of the lipocalin or Q 2n-microglobulin superfamily of carrier proteins (Preti etal, 1992 Zeng etal, 1996a,b). 

Zeng, C., Spielman, A. L, Vowels, B. R., etal. (1996a). A human axillary odorant is carried by apolipoprotein D. Proceedings ofthe National Academy of Sciences of the USA 93,6626-6630. 

A marked increase in apolipoprotein D immunoreactivity is observed in hippocampus following neurotoxicity induced by KA (Table 6.3) (Ong et al., 1997). This increase in apolipoprotein D immunoreactivity occurs on the first day after KA injection, mainly in the cell bodies and dendrites of neurons (Fig. 6.3 A, 3B). Unlike the gray matter, no increase is observed in white matter tracts (Ong et al., 1997a). The significance of this upiegulation of apolipoprotein D remains unknown. However, apolipoprotein D binds to arachidonic acid (Morais Cabral et al., 1995), which is released by PLA2 stimulation. This could be a protective mechanism to limit the oxidative products from arachidonic acid, e.g. 4-HNE, after kainate injection. 

Fig. 6.3 Apolipoprotein D immunoreactivity in field CA1 of the hippocampus. A section from a normal rat, showing occasional labeled neurons (arrow). B section from a 1 day post-kainate inected rat, showing dense staining in pyramidal neurons (arrows). Scale = 160 /xm. Reproduced with kind permission from Ong et al., 1997, Neuroscience 79 359-367. Pergamon...

Morais Cabral J. H., Atkins G. L., Sanchez L. M., Lopez-Baodo Y. S., Lopez-Oton C., and Sawyer L. (1995). Arachidonic acid binds to apolipoprotein D Implications for the protein s function. FEBS Lett. 366 53-56. 

Patel S. C., Asotra K., Patel Y. C., McConathy W. J., Patel R. C., and Suresh S. (1995). Astrocytes synthesize and secrete the lipophilic ligand carrier apolipoprotein D. NeuioReport 6 653-657. 

In addition to vitamin E, intracellular levels of ROS are controlled by a number of free radical scavenging enzymes including superoxide dismutase, catalase, peroxidase, heme oxygenase, proteins including ferritin and apolipoprotein D,... 

Walker D. W., Muffat J., Rundel C., and Benzer S. (2006). Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr. Biol. 16 674-679. 

Apolipoprotein D, a glycoprotein referred to originally as thin-line polypeptide, is an apolipoprotein of Mr 22,700 found in HDL and VLDL (A6, L7, M2, M3). Kostner (K18) has described thin-line polypeptide, which he termed apoA-III. The amino acid composition of apoA-III differs from that described for apoD nevertheless, many workers have assumed that apoA-III is apoD. ApoA-III has been reported to be a potent activator of lecithimcholesterol acyltransferase (K17, 06), but apoD, though associated with LCAT (vide infra) appears not to activate the enzyme (A16). It appears quite possible, therefore, that apoD and apoA-III are different apolipoproteins. 

C25. Curry, M. D., McConathy, W. J., and Alaupovic, P., Quantitative determination of human apolipoprotein D by electroimmunoassay and radial immunodiffusion. Biochim. Biophys. Acta 491, 232-241 (1977). 

M6. Mahadevan, V., and Soloff, L. A., A method for isolating human plasma lecithimcho-lesterol acyltransferase without using anti-apolipoprotein D, and its characterization. Biochim. Biophys. Acta 752, 89-97 (1983). 

M41. Morton, R. E., and Zilversmit, D. B., The separation of apolipoprotein D from cho-lesteryl ester transfer protein. Biochim. Biophys. Acta 663, 350-355 (1981). 

Absorption, distribution, metabolism, elimination 5 -adenylyl /1-y-imidodiphosphate Aminohexanoic acid Adenosine monophosphate Apolipoprotein D... 

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