Primary brain tumors

Rubin JB, Kung AL, Klein RS, et al. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 2003 100 13513-8. 

Hunter SB, Varma V, Shehata B, et al. Apolipoprotein D expression in primary brain tumors analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue. J. Histochem. Cytochem. 2005 53 963-969. 

Bigner DD, Bigner SH, Burger PC, et al. 1986. Primary brain tumors in Fischer 344 rats chronically exposed to acrylonitrile in their drinking water. Food Chem Toxicol 24 129-137. 

In a chronic inhalation bioassay in rats exposed for 6 hours/day, 5 days/week for 2 years to 100, 33, or 10ppm ethylene oxide, there was a dose-related increased occurrence of mononuclear cell leukemia in both sexes at all concentrations. There was also an increased occurrence of primary brain tumors at 100 and 33 ppm in both sexes and peritoneal mesotheliomas arising from the testicular serosa at 100 and 33 ppm in male rats. ... 

Carmustine and lomustine can produce remissions that last from 3 to 6 months in 40 to 50% of patients with primary brain tumors. Both drugs also are used as secondary treatment of Hodgkin s disease and in experimental combination chemotherapy for various types of lung cancer. Other tumors in which remission rates of 10 to 30% have been obtained are non-Hodgkin s lymphomas, multiple myeloma, melanoma, renal cell carcinoma, and colorectal cancer. 

Malignant neoplasms of the nervous system occur with an incidence of 5-6/ 100,000 inhabitants/year [197], Besides meningeomas cerebral gliomas are the most frequent primary brain tumors. Primary treatment comprises surgical resection, irradiation and chemotherapy. However, survival and quality of life are still limited. For the diagnosis and differential diagnosis of brain tumors. 

Carmustine BCNU, BiCNU Primary brain tumors Hodgkin disease non-Hodgkin lymphomas multiple myeloma Blood disorders (thrombocytopenia, leukopenia] Gl distress (nausea, vomiting] hepatotoxicity pulmonary toxicity... 

Disorders with space-occupying effect Primary brain tumor Metastatic brain tumor Subdural hematoma (posttrauma) Normal-pressure hydrocephalus Neurosurgical management... 

Levin VA, Chamberlain MC, Prados MD, Choucair AK, Berger MS, Silver P, Seager M, Gutin PH, Davis RL, Wilson CB. Phase I-II study of eflornithine and mitogua-zone combined in the treatment of recurrent primary brain tumors. Cancer Treat Rep 1987 71(5) 459-64. 

In a retrospective cohort study in 83 patients with primary brain tumors who were treated with procarbazine, 20 patients had procarbazine hypersensitivity reactions (4). There was a significant association between exposure to antiepileptic drugs and the development of procarbazine hypersensitivity reactions. The authors suggested that this association may have been due to a reactive intermediate generated by induction of CYP3A. 

Hodgkin s disease non-Hodgkin s lymphoma primary brain tumor melanoma... 

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