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Apitz-Castro

During the early part of my scientihc work, I spent 17 years as a professor in the Department of Chemistry at Indiana University. During that period, I had, among others, two talented coworkers Mahendra Jain as a post-doctoral fellow and Rafael Apitz-Castro as a visiting professor from the Institute Venezolano de Investigaciones Cientificas (IVIC) in Caracas, Venezuela. These two former coworkers did the most important work on ajoene. It is always great to see former colleagues go on to do important work. [Pg.98]

Borsch-Haubold AG, Bartoli F, Asselin J, Dudler T, Kramer RM. Apitz-Castro R, Watson SP, Gelb MH. (1998). Identification of the phosphmylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. J. Biol. Chem. 273,4449-4458. [Pg.312]

Garcia, A.J. Apitz-Castro, R. Plasma total homocysteine quantitation An improvement of the classical high-... [Pg.1689]

Apitz-Castro, R., Badimon, J J. and Badimon, L. (1992) Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Thromb. Res. 68 145-155. [Pg.232]

Rendu F, Daveloose D, Debouzy JC, BourdeauN, Levy-Toledano S, Jain MK, Apitz-Castro R. Ajoene, the antiplatelet compound derived from garlic, specifically inhibits platelet release reaction by affecting the plasma membrane internal microviscosity. U 150 INSERM, URA 184 CNRS, Hopital Lariboisiere, Paris, France. [Pg.165]

Ledezma E, Lopez JC, Marin P, Romero H, Ferrara G, De Sousa L, Jorquera A, Apitz Castro R. Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafme. Arzneimittelforschung 1999 49 544-547. [Pg.165]

The mechanism by which thrombin activates phospholipase is presently unknown. Touqui et have provided evidence for the presence of the phospholipase A2 inhibitor, lipocortin, in blood platelets and have suggested that its phosphorylation during the platelets response to thrombin relieves inhibition and allows arachidonic acid release. On the other hand, Apitz-Castro d al. have suggested that phosphatidic acid (made available subsequent to phospholipase C acting on phosphoinositides) changes the state of organization of the phospholipids in the platelet membrane making them more susceptible to attack by phospholipase A2. [Pg.6]

Apitz-Castro, R., Cruz, R., Mas, M. and Jain, M.K. (1981). Further studies on a phospholipase A2 isolated from human platelet plasma membranes. Thrombosis. Res., 23, 347-354... [Pg.12]

Apitz-Castro R, Badimon JJ, Badimon L (1994) A garlic derivative, ajoene, inhibits platelet deposition on severely damaged vessel wall in an in vivo porcine experimental model. Thromb Res 75(3) 243-249... [Pg.3692]

Teranishi K, Apitz-Castro R, Robson SC, Romano E, Cooper DK (2003) Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation 10(4) 374—379... [Pg.3692]

Apitz-Castro R, Ledezma E, Escalante J, Jain MK (1986) The molecular basis of the antiplatelet action of ajoene direct interaction with the fibrinogen receptor. Biochem Biophys Res Commun 141(1) 145-150... [Pg.3694]

Apitz-Castro R, Jain MK, Bartoli F, Ledezma E, Ruiz MC, Salas R (1991) Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional Ilb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene. Biochim Biophys Acta 1094(3) 269-280... [Pg.3694]

Ajoene was discovered as the most potent platelet inhibitor from an oil-macerated crushed garlic (Apitz-Castro et al 1983), and they revealed that ajoene inhibited both of the arachidonate metabolism and the membrane G-protein level signal transduction of platelets (Apitz-Castro eta/. 1986a, 1986b, 1988). [Pg.444]

Apitz-Castro, R., Cahrera, S., Cruz, M.R., Ledezma, E., and Jain, M.K. 1983. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachi-donate metaholism, release reaction and platelet ultrastructure. ThrombRes 32(2) 155 169. [Pg.449]

Apitz-Castro, R., Escalante, J., Vargas, R., and Jain, M.K. 1986a. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, foiskolin, indo-methacin and dypiridamole on human platelets. Thromb Res 42(3) 303 311. [Pg.449]

See other pages where Apitz-Castro is mentioned: [Pg.708]    [Pg.708]    [Pg.1409]    [Pg.1489]    [Pg.1669]    [Pg.499]    [Pg.27]    [Pg.27]    [Pg.226]    [Pg.504]    [Pg.507]    [Pg.312]    [Pg.339]    [Pg.496]    [Pg.842]    [Pg.249]    [Pg.429]    [Pg.475]    [Pg.220]    [Pg.482]    [Pg.483]    [Pg.484]    [Pg.484]    [Pg.429]    [Pg.708]    [Pg.708]    [Pg.2391]    [Pg.78]    [Pg.78]    [Pg.457]    [Pg.444]   
See also in sourсe #XX -- [ Pg.98 ]



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