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Thrombi Platelets

Platelet aggregation increases like an avalanche because, once activated, platelets can activate other platelets. On the injured endothelial cell, a platelet thrombus is formed, which obstructs blood flow. Ultimately, the vascular lumen is occluded by the thrombus as the latter is solidified by a vasoconstriction produced by the release of serotonin and thromboxane A2 from the aggregated platelets. When these events occur in a larger coronary artery, the consequence is a myocardial infarction involvement of a cerebral artery leads to stroke. [Pg.148]

Goto S. Understanding the mechanism of platelet thrombus formation under blood flow conditions and the effect of new antiplatelet agents. Curr Vase Pharmacol. 2004 2 23-32. [Pg.364]

Coller BS, Smith SR, Scudder LE et al. (1989) Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GP Ilb/IIIa receptor correlation with bleeding time, platelet aggregation and blockade of GP Ilb/IIIa receptors. Circulation 80 1766-1774... [Pg.281]

Folts JD, Rowe GG (1988) Epinephrine reverses aspirin inhibition of in vivo platelet thrombus formation in stenosed dog coronary arteries. Thromb Res 50 507-516... [Pg.281]

Denis C, Methia N, Frenette PS et al. (1998) A mouse model of severe von Willebrand disease defects in hemostasis and thrombosis. Proc Natl Acad Sci USA 95 9524-9529 Ni H, Denis CV, Subbarao S et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest 106 385-392... [Pg.309]

Nakahara T, Yokochi T, Kamisaka Y, Yamaoka M, Suzuki O, Sato M, Okazaki S, and Ohshima N. (1990). Inhibitory effects of mold oil including gamma-linolenate on platelet thrombus formation in mesenteric microvessels in the rat Thromb. Res. 57,371. [Pg.288]

Ruggeri, ZNi Mechanisms initiating platelet thrombus formation. Thmmb. Haemost. 1997 78 611-616. [Pg.333]

OrvimU, Roald HE, Stqrhens RW, Roos N, Sakariassen KS Tissue factor-induced coagulation triggers platelet thrombus formation as effidently as fibrillar collagen at arterial blood flow conditions. Arteriosder Hirottd) 14 1976-1983,1994. [Pg.358]

Salatti JA, FenUm J, Anton P, Sakariassen KS alpha-Thrombin bound to extracdlular endothelial matrix induces pronounced fibrin deposition and platelet thrombus growth in flowing non-antiooagulated human blood. Blood Coagul Fibrin 5 561-566,1994. [Pg.358]

TsdK TB, Baumgartner HR Platelet adhesion and mural platelet thrombus fomatkm on aortic subendothdium of rats, rabbits, and guinea pigs corrdate negatively with the vascular PGI2 productiem. J Lab Clin Med 98 402-411,1981. [Pg.359]

Esoolar G, Garrido M, Aznar-Salatti J, Ordinas A, Bastida E Con >arison between human umbilical artery and rabbit abdominal aorta as substrata for platdet adhesion and platelet thrombus fi>nnation under flow conditions Blood Vessels 28 520-531,1991. [Pg.359]

Lominadze, D., Joshua, I. G. and Schuschke, D. A In vivo platelet thrombus fermation in microvessels... [Pg.453]

Apitz-Castro, R., Badimon, J J. and Badimon, L. (1992) Effect of ajoene, the major antiplatelet compound from garlic, on platelet thrombus formation. Thromb. Res. 68 145-155. [Pg.232]

Z. M. Ruggeri Mechanisms initiating platelet thrombus formation. Thrombosis and Haemostasis 78, 611 (1997) [published erratum appears in Thrombosis and Haemostasis 78, 1304 (1997)] [see comments]. [Pg.872]

Figures 12 and 13 are scanning electron micrographs showing the surface of y-globulin-coated PVC after 5 min of blood contact time. Platelets appear to cover the surface uniformly with little evidence of basal fibrin. The large spherical platelet thrombus in Figure 12 also contained no visible fibrin basal to the platelet thrombus. Figures 12 and 13 are scanning electron micrographs showing the surface of y-globulin-coated PVC after 5 min of blood contact time. Platelets appear to cover the surface uniformly with little evidence of basal fibrin. The large spherical platelet thrombus in Figure 12 also contained no visible fibrin basal to the platelet thrombus.
Figure 12. The y-globulin coated-PVC after 5 min of blood exposure showing randomly scattered platelets, occasional leukocytes, and a large spherical platelet thrombus. Figure 12. The y-globulin coated-PVC after 5 min of blood exposure showing randomly scattered platelets, occasional leukocytes, and a large spherical platelet thrombus.
Ruggeri, Z.M., Mechanisms initiating platelet thrombus formation. Thromb Haemost, 1997. 78(1) p. 611-6. [Pg.241]

Chesebro, H.J., Lam, J.Y.T. and Fuster, V. (1986). The pathogenesis and prevention of aortocoronary vein bypass graft occlusion and restenosis after arterial angioplasty role of vascular injury and platelet thrombus deposition. ]. Am. Coll Cardiol, 8, 57B-66B... [Pg.157]

DeBoer LW, Folts JD (1989) Garlic extract prevents acute platelet thrombus formation in stenosed canine coronary arteries. Am Heart J 117(4) 973-975... [Pg.3692]

See other pages where Thrombi Platelets is mentioned: [Pg.168]    [Pg.302]    [Pg.41]    [Pg.432]    [Pg.272]    [Pg.273]    [Pg.297]    [Pg.168]    [Pg.11]    [Pg.29]    [Pg.176]    [Pg.269]    [Pg.275]    [Pg.343]    [Pg.37]    [Pg.182]    [Pg.758]    [Pg.10]    [Pg.33]    [Pg.391]    [Pg.37]    [Pg.239]    [Pg.211]    [Pg.358]    [Pg.11]    [Pg.369]    [Pg.183]    [Pg.100]    [Pg.3678]    [Pg.79]   
See also in sourсe #XX -- [ Pg.192 ]



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