Antiviral compounds polysaccharides

The pharmacologically active constituents of these Astragalus belong to two different kinds of chemical compounds, polysaccharides and saponins, and the most interesting pharmacological properties are hepatoprotective, immunostimulant and antiviral. 

As regards the antiviral compounds derived from microorganisms, the polysaccharides nostoflan and naviculan proved to be active against influenza A virus [54,97]. Chemically synthesized oversulfated derivatives of extracellular GAG and SP, produced by a marine Pseudomonas, prepared by dicyclohexylcarbodiimide-mediated reaction for both polysaccharides, showed antiviral activities against influenza virus type A but not against type B [52],... 

Among the natural compounds, polysaccharides represent a class of natural products with a significant antiviral activity, suggesting that they could be explored as novel antiviral agents (Table 1.3). 

Mourier s report was quickly followed by successful enantiomeric resolutions on stationary phases bearing other types of chiral selectors, including native and deriva-tized cyclodextrins and derivatized polysaccharides. Many chiral compounds of pharmaceutical interest have now been resolved by packed column SFC, including antimalarials, (3-blockers, and antivirals. A summary is provided in Table 12-2. Most of the applications have utilized modified CO, as the eluent. 

Abstract The inhibitory action of polyanionic substances on virus replication was reported more than 50 years ago. Seaweeds, marine invertebrates, and higher plants represent abundant sources of novel compounds of proved antiviral activity. Natural sulfated polysaccharides (SPs) are potent in vitro inhibitors of a wide variety of enveloped viruses, such as herpes simplex virus (HSV) types 1 and 2, human immunodeficiency virus (HIV), human cytomegalovirus (HCMV), dengue virus (DENV), respiratory syncytial virus (RSV), and influenza A virus. Several polysulfate compounds have the potential to inhibit virus replication by blocking the virion binding to the host cell. In contrast, their in vivo efficacy in animal and human systemic infections has undesirable draw-... 

There are many classes of chemical compounds with putative antiviral effects. One such class is known broadly as sulfated polysaccharides (SPs). They... 

Ehresmann, D.W., Deig, E.E., and Hatch, M.T. (1979) Antiviral properties of algal polysaccharides and related compounds, in Marine Algae in Pharmaceutical Science (eds H.A. Hoppe, T. Levring, and Y. Tanaka), Walter de Gruyter, Berlin, New York, pp. 293-302. 

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