Antiulcer effects

An interesting aspect of me antiulcer effect of quercetin is mat it has been shown to inhibit the growth of Helicobacter pylori in a dose-dependent manner in vitro. 

More recently, nitric oxide has been claimed to contribute to the antiulcer effect of carbenoxolone. 

Interactions between nutraceuticals and prescribed medicines or even other nutraceuticals are being reported. Interactions between nutraceuticals and medicines include those experienced with melatonin, which was shown to exacerbate methamphetamine-induced neurochemical effects, again in animal studies policosanol has been shown to stimulate the antiulcer effects of... 

Valdes, S. Molina, V. Carbajal, D. Arruzazabala, L. Mas, R. Comparative study of the antiulcer effects of D-002 with sucralfate and omeprazole. Rev. CENIC Cienc. Biol. 2000, 31, 117-120. 

Sucralfate is minimally ab.sorbed from the GI tract and thus exerts its antiulcer effect through local rather than sy>-temic action. It has negligible aeid-neutralizing orbufferine eapacity in therapeutic doses. 

Many other flavonic compounds have been reported to exhibit an interesting antiulcer effect mecyadanol, (+)-cyanidanol-3, (+)-catechin, 3-0-methyl-(+)-catechin, 3-methoxy-5,7,3 ,4 -tetrahydroxyflavan, apigenin-7,4 -diorthomethylether, hesperidin, and amentoflavone [118-121],... 

By contrast, the inhibition of neutrophil infiltration did not appear to be involved in the antiulcer effect of quercetin in gastric mucosal injury induced by 50% ethanol, an experimental model in which there is a considerable leukocyte influx into the gastric mucosa [110]. 

In addition to antisecretory mechanisms, the enhancement of the defensive mucosal factors seems to play an important role in the antiulcer effects of... 

The antiulcer effect of some flavonoids might be related to their ability to increase the mucosal levels of these prostanoids. This is the case of solon, which inhibits the metabolizing enzyme 15-OH-PG-DH 15-hydroxy-pro staglandindehydrogenase [83]. The cytoprotective mechanism would be similar to the one of carbenoxolone, a drug frequently used in experimental models because of its ability to stimulate the mucosal defenses. 

Other flavonoids that are able to enhance the luminal release of PG in vivo are the glucoside of hypolaetin [117], the anthocyanidin pigment IdB 1027 [213], and the flavonic extract of Bidens aurea [214] therefore their antiulcer effect could be related to an enhancement of PGE2 levels in gastric mucosa and also to a generalized stimulation of the defensive mucosal mechanisms. 

S. Onodera, M. Tanaka, M. Aoyama, Y. Arai, N. Inaba, T. Suzuki, A. Nishizawa, M. Shibata, Y. Sekine (1999) Antiulcer effect of lafutidine on indomethacin-induced gastric antral ulcers in refed rats. Jpn. J. Pharmacol., 80, 229-235. 

Alqasoumi, S. 2012. Anti-secretagogue and antiulcer effects of Cinnamon Cinnamomum zeylanicum in rats. Journal of Pharmacognosy and Phytotherapy, 4 53-61. 

Watanabe K, Goto Y, Hara N, Kanaoka S 1981 Neuronal factors involved in the pathogenesis of experimental ulceration and antiulcer effect of magnolol, an active component of Magnolia bark. Wakanyaku Shinpojumi(Kiroku) 14 1-6... 

Yamahara J, Kobayashi M, Miki K, Kozuka M et al. 1985 Cholagogic and antiulcer effect of Saussureae radix and its active components. Chem Pharm Bull 33 1285-1288... 

Antiulcer effect. EPO, administered at 5 and 10 mg/kg via gastric intubation, was effective... 

Dried ethanol and acetone extracts of fresh rhizome are given orally significantly inhibited gastric secretion of induced acute stress in rats, producing an antiulcer effect. The antiulcer effect may also be mediated through the inhibitory effect of ginger on Helicobacter pylori ... 

The flavonoids in peppermint leaves reportedly have choleretic activity in dogs. Azulene isolated from peppermint had antiinflammatory and antiulcer effects in experimental animals. ... 

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