Antisecretory

The mechanism by which sucralfate accelerates healing of duodenal ulcers has not been determined. It does not have significant antisecretory, acid neutralizing activity or direct stimulation of ulcer healing. It is known that the mechanism is local rather than systemic. Binding of pepsin or bile salts may contribute to its effect. It is indicated for the short-term therapy of active duodenal ulcers and for maintenance at reduced dosage. 

Bismuth Subsalicylate. (2-Hydroxybenzoato-0 )-oxobismuth [14882-18-9] (Pepto-Bismol) maybe made by the process described in Reference 10. Bismuth subsaHcylate has been shown to bind toxins produced by several bacterial strains. It may also act as a result of its saHcylate component on prostaglandin formation and have specific intestinal antisecretory activity. It has been found to be effective in the prevention and therapy of... 

Antisecretory. An agent that decreases the secretion of digestive juices in the stomach. 

A partially reduced quinoline derivative with antiulcerative and antisecretory activities is isotiquimide (14). It may be synthesized by metallating (with n-BuLi) 4-methyl-5,6,7,8-tetrahy-droquinoline and condensing this with dimethylmethoxysilylisothiocyanate to produce the desired thioamide isotiquimide (14) [4],... 

ATC A02BC02 A02BD04 Use antisecretory, gastric HYK -ATPase inhibitor... 

TURNBERG L A (1983) Antisecretory activity of opiates in vitro and in vivo in man. Scand J Gastroenterol Suppl. 84 79-83. 

I The cornerstone of rotavirus treatment is supportive care and rehydration with ORT or intravenous fluids if necessary. Antimotility and antisecretory agents should not be used... 

Volume I). The most rapid metabolic deactivating reaction is oxidation to the bioinert C15 oxo prostaglandins. Converting the latter to a tertiary methyl carbinol led to the desired orally active gastric antisecretory agents. 

In healthy individuals URT flora multiplies in gastric aspirate during treatment with antisecretory compounds and in particular proton pump inhibitors [34, 40, 44], This concerns viridans streptococci, coagulase-negative staphylococci, Haemophilus sp., diphtheroids, Moraxella sp., lactobacilli, and other streptococci, most of which are Gram-positive bacteria. With dedicated measures anaerobic species of oral origin are also recovered [66]. 

Because the development of antibiotic resistance will continue to be a problem, the development of effective alternative treatments is imperative. Immunization, probiotics, antisecretory agents, improved oral rehydration and nutrition therapy and nonabsorbable antibiotics are being considered by clinicians and researchers. Novel... 

Scarpignato C, Pelosini I Antisecretory drugs for eradication of Helicobacter pylori Antibacterial activity and synergism with antimicrobial agents. Progr Basic Clin Pharmacol 1999 11 136-180. 

The prostaglandin Ei and E2 analogues showing antisecretory and cytoprotective activities49,50 had to be deuterium or tritium labelled for preclinical studies. The tritiated or deuteriated title compounds 61, 62 and 63 have been synthesized51 by the methods outlined in equations 25, 26 and 27. Compounds 61 and 62, with hydrogen at 7-position... 

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