Antipsychotic haloperidol

Antipsychotics Haloperidol 025 1-3 Psychosis hallucinations, delusions, suspiciousness... 

A few typical examples of CBR-catalyzed reduction of xenobiotics include the reduction of the antipsychotic haloperidol (6), the P450 inhibitor metyrapone (6), the oral hypoglycemic acetohexamide (6), and the anticoagulant warfarin (7). 

It may be fair to ask, Is this much ado about nothing Although test tube studies have shown that particular drugs interact, it is seldom that this causes problems for patients taking the medications. For example, the antidepressant fluvoxamine inhibits the enzyme that deactivates the antipsychotic haloperidol (Haldol). Does this mean that fluvoxamine and haloperidol cannot be taken together By no means. Although this would probably raise the blood level of haloperidol somewhat, the main effect if any would be that a smaller dose of haloperidol would be more effective. 

Typical Antipsychotics. The high potency antipsychotic haloperidol (Haldol) and low potency antipsychotics chlorpromazine (Thorazine) and thioridazine (Mellaril) have also been used to treat ADHD. Although they provide a tranquilizing effect (they are in fact sometimes called major tranquilizers ) that can reduce hyperactivity and impulsivity, antipsychotics remain markedly less effective than stimulants. Antipsychotics do not noticeably improve attention in patients with ADHD, and at this time the typical antipsychotics cannot be considered a reasonable monotherapy in uncomplicated ADHD. 

The high potency antipsychotic haloperidol (Haldol) provides the same calming effects with minimal anticholinergic effects. Although haloperidol is very effective, dementia patients are quite sensitive to its extrapyramidal effects. These include stiffness, shuffling gait, a mask-like facial appearance, and involuntary movements. To minimize these effects, haloperidol is used in very low doses (0.5-1.0mg) when treating those with dementia. 

Encephalopathic syndrome - An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness, confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, blood urea nitrogen, fasting blood sugar) has occurred in a few patients treated with lithium plus an antipsychotic (haloperidol). 

Prior to the introduction of atypical antipsychotics, haloperidol was one of the most preferred antipsychotics... 

Medication may be seen by the patient as intrusive and controlling or, alternatively, as comforting—a transitional, object-like extension of the therapist. Patients will be prone to interpret the medication in psychotic ways, especially when they are more symptomatic (and more in need of medication). When compliance remains a significant problem, consideration may be given to using one of the long-acting injectable forms of the antipsychotics (haloperidol decanoate or fluphenazine de-canoate). 

Amitriptyline -Clomipramine Desipramine Imipramine Paroxetine Antipsychotics Haloperidol Risperidone Thioridazine Codeine... 

After first trimester carbamazepine, lamotrigine, oxcarbazepine, or valproate Second choice benzodiazepine (lorazepam) Third choice calcium channel blocker With psychosis first choice adjunctive high-potency typical antipsychotic (haloperidol, perphenazine, thiothixene, or trifluoperazine)... 

Fluphenazine Antipsychotic Haloperidol drugs Perphenazine Thioridazine... 

Blood levels clearly correlate with therapeutic response for a minority of the psychotropic drugs, including the antipsychotics haloperidol, clozapine, and olanzapine the tricyclic antidepressants and the mood stabilizer lithium. 

Figure 10.10 Top antipsychotics haloperidol and risperidone. Bottom H3 receptor antagonists/inverse agonists ciproxifan and ABT-239 (Zhang, M., et ah Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs. Brain Res. 2005, 1045, 142-149).

A large number of unnatural molecules derived from these heterocycles are of great pharmaceutical importance, many of them being drug molecules currently in the market. Representative examples are shown in Figure 3.2, and include the antipsychotic haloperidol, the antidepressant paroxetine, the anti-HIV palinavir, the antihypertensive amlodipine, the cholesterol-lowering agent torcetrapib, and the mitosis inhibitor monastrol. 

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