Weight gain antipsychotic drugs

Antipsychotic drugs weight gain and diabetes meUitus... 

Several antipsychotic drugs/weight gain 5-HT2C receptors 123 Conflicting results SEDA-27, 53... 

Wetterling T. Bodyweight gain with atypical antipsychotics. A comparative review. Drug Saf 2001 24(l) 59-73. Blin O, Micallef J. Antipsychotic-associated weight gain and clinical outcome parameters. J Clin Psychiatry 2001 62(Suppl 7) 11—21. 

Allison, D. B. and D. E. Casey (2001). Antipsychotic-induced weight gain a review of the literature. J Clin Psychiatry 62(Suppl 7) 22-31. Anttila, S. A. and E. V. Leinonen (2001). A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 7(3) 249-64. Baptista, T., N. M. Kin, S. Beaulieu and E. A. de Baptista (2002). Obesity and related metabolic abnormalities during antipsychotic drug administration mechanisms, management and research perspectives. Pharmacopsychiatry. 35(6) 205-19. 

Baptista T. Body weight gain induced by antipsychotic drugs mechanisms and management. Acta Psychiatr Scand 1999 100(1) 3—16... 

Kroeze, W. K., Hufeisen, S. J., Popadak, B. A. et al. HI-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28 519-526, 2003. 

Nevertheless, some atypical antipsychotic drugs, such as clozapine and olanzapine, have been linked to substantial weight gain, hyperlipidemia and type II diabetes, a new range of medically serious side-effects. 

Kim, S.F., Huang, A.S., Snowman, A.M., Teuscher, C. and Snyder, S.H. (2007) From the coven Antipsychotic drug-induced weight gain mediated by histamine HI receptor-linked activation of hypothalamic AMP-kinase. Proceedings of the National Academy of Sciences of the United States of America, 104 (9), 3456-3459. 

Despite the widespread use of neuroleptics in maintenance treatment of bipolar disorder, there have not been any systematic studies of their suitability for this role. Through clinical experience it has been widely accepted that neuroleptics are useful adjunctive treatments to lithium and related drugs. Treatment refractory patients frequently respond to atypical antipsychotics such as clozapine or risperidone. Such adverse effects as EPS, cognitive dysfunction and weight gain frequently limit the long-term use of classical neuroleptics. For this reason, the atypical neuroleptics such as olanzapine and risperidone should now be considered as alternatives for maintenance treatment. 

Atypical antipsychotics have advantages in tolerabihty and safety over the older drugs. They have a lower incidence of extrapyramidal movement disorders, but may cause sedation and weight gain. Their metabolism by CYP450 enzymes leads to a potential for interaction with many co-prescribed drugs. 

Besides weight gain, probably the most common side effect from antipsychotics in young people is sedation. Histamine receptor blockade appears to mediate this side effect. Excessive sleepiness can interfere with a youth s academic performance, cause sluggishness, and cause a child to appear drugged to their peers and family. 

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