Antimicrobial peptides delivery

Rosenfield, C.-L., Samuelian, S., Vidal, J.R., Reisch, B.I., 2010. Transgenic disease resistance in Vitis vinifera potential use and screening of antimicrobial peptides. Am. J. Enol. Vitic. 61,348-357. Sanford, J.C., Klein, T.M., WoU, E.D., Allen, N., 1987. Delivery of substances into ceUs and tissues using a particle bombardment process. Part. Sci. Technol. 5, 27-37. 

Sulfobutylether P-cyclodextrin can form noncovalent complexes with many types of compounds including small organic molecules, peptides, and proteins. It can also enhance their solubility and stability in water. The first application of sulfobutylether P-cyclodextrin was in injectable preparations it can also be used in oral solid and liquid dosage forms, and ophthalmic, inhalation, and intranasal formulations. Sulfobutylether P-cyclodextrin can function as an osmotic agent and/or a solubilizer for controlled-release delivery, and has antimicrobial preservative properties when present at sufficient concentrations. 

Faraj, J.A. Dorati, R. Schoubben, A. Worthen, D. Selmin, R Capan, Y. Leung, K. DeLuca, P.P. Development of a peptide-containing chewing gum as a sustained release antiplaque antimicrobial delivery system. AAP5 Pharm. Sci. Tech. 2007, 8 (1), 177-185. 

Several peptides have been studied with antimicrobial and antifungal properties for BBB delivery to avoid infections. Cholesterol-conjugated G3R6TAT (CG3R6TAT) cationic nanoparticles exhibited strong antimicrobial activities against various types of microbes in vitro. This peptide contains the TAT sequence. The prepared nanoparticles were investigated for treatment... 

Antimicrobial and antiendotoxin cationic peptide, CM3, incorporated into liposomes was suggested for the aerosol delivery, and corresponding models describing its potential distribution in lungs of patients with different breathing patterns have been developed.Liposomes with calcitonin have been developed for intranasal delivery. Liposomal forms of the peptide antibiotic, polymyxin B, showed certain promise in different models.355-357... 

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