Antiglomerular basement membrane

Glomerular damage Accelerated hypertension Systemic lupus erythematosus Poststreptococcal glomerulonephritis Antiglomerular basement membrane disease... 

In the circulation of the BN rat there is a simultaneous and transient presence of antiglomerular basement membrane antibodies and circulating immune complexes [175]. Another characteristic is a striking increase in total and antigen-specific IgE level [190], which also has been found in Hooded Lister rats [ 191 ], as well as anti-single-stranded DNA antibodies [ 181] in the BN rat. In PVG/C rats [192, 193], mercuric chloride also induced glomerulopathi and antinuclear antibodies directed against non-histone nucleoprotein. 

Bindi P, Gilson B, Aymard B, Noel LH, Wieslander J. Antiglomerular basement membrane glomerulonephritis following D-penicillamine-associated nephrotic syndrome. Nephrol Dial Transplant 1997 12(2) 325-7. 

Peces R, Navascues RA, Baltar J, Seco M, Alvarez J.Antiglomerular basement membrane antibody-mediated glomerulonephritis after intranasal cocaine use. Nephron 1999 81 434-438. 

Regan S, Turgeon C. 1986. Lack of antiglomerular basement membrane antibody binding to alveolar membranes after hydrocarbon exposure in rats. J Clin Lab Immunol 20 147-149. 

Potential biomarkers for the autoimmune effects of mercury include measurement of antiglomerular basement membrane antibodies, anti-DNA antibodies, serum IgE complexes, and total IgE (Cardenas et al. 1993). Elevated IgE, antiglomerular basement membrane antibodies, and anti-DNA antibodies have been observed in a few persons with exposure to mercury from dental amalgams (Anneroth et al. 1992). Other individuals have also been shown to have elevated anti-DNA or antiglomerular basement membrane antibodies (Cardenas et al. 1993 Langworth et al. 1992b). 

Intraperitoneal administration of berberine at a dosage of 0.1 mg/kg inhibited antiglomerular basement membrane nephritis in rats. The LDJ0 of the alkaloid was > 1 g/kg after oral administration. Tablets containing the alkaloid were formulated for oral administration [254]. 

Can be immune complex-mediated, antiglomerular basement membrane antibody-mediated, or associated with antineutrophil cytoplasmic autoantibodies. 

Serum complement levels are useful to distinguish between various forms of acute nephritis that may be due to either a primary renal disorder or a systemic disease. Glomerular diseases associated with decreased complement levels include systemic diseases such as systemic lupus erythematosus, subacute bacterial endocarditis, and cryoglobulinemia, and renal diseases such as acute poststreptococcal glomerulonephritis. Glomerular diseases in which serum complement levels are normal include systemic diseases such as Goodpasture s syndrome and renal diseases such as IgG-IgA nephropathy, antiglomerular basement membrane disease, and immune-complex disease. 

Ball JA Young KR Jr (1998) Pulmonary manifestations of Goodpasture s syndrome. Antiglomerular basement membrane disease and related disorders. Clin Chest Med, 19(4) 777-791. 

A. Antiglomerular basement membrane antibodies Some xenobiotics may induce an immune-type glomerulonephritis associated with the occurrence of antibodies against some constituents of the glomerular basement membrane. These antibodies may be directly responsible for the nephropathy or they may be produced as a consequence of non- specific alterations of the normal glomerular basement membrane lattice. 

Allergy blood testing Allergy skin testing Anticardiolipin antibodies Anticentromere antibody Antideoxyribonuclease-B titer Anti-DNA antibody Anti-extractable nuclear antigens Antiglomerular basement membrane antibody... 

Lemer RA, Glassock KJ, Dixon FJ. The role of antiglomerular basement membrane antibody in the pathogenesis of human glomemlonephritis. J Exp Med 1%7 126 989-1004. 

Arends J, Wu J, Borillo J, et al. T ceU epitope mimicry in antiglomerular basement membrane disease. J Immunol 2006 176 1252-1258. 

Kitching AR, Turner AL, Semple T, et al. Experimental autoimmune antiglomerular basement membrane glomerulonephritis a protective role for IFN-gamma. J Am Soc Nephrol 2004 15(7) 1764-1774. 

Savage CO, Pusey CD, Bowman C, et al. Antiglomerular basement membrane antibody mediated disease in the British Isles 1980-1984. Br Med J 1986 292 (6516) 301 304. 

Drube S, Mamin N, Sieberih HG. Coincidence of myasihenia gravis and antiglomerular basement membrane glomerulrxiephritis combination of two antibrxly-mediated autoimmune diseases on day 15. Nephrol Dial Transplant 1997 12 1478-1480. 

Kirkland GS, Savige J, Sinclair RA, et al. Polyarteritis nodosa and antiglomerular basement membrane disease without antineutrophil cytoplasm antibodies. Am J Nephrol 1996 16 442 5. 

Szczech LA, Anderson A, Ramers C, et al. The uncertain significance of antiglomerular basement membrane antibody among HIV-infected persons with kidney disease. Am J Kidney Dis 2006 48 E55-E59. 

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