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Antifungal drugs topical

The ongoing assessment involves careful observation of the patient every 2 to 4 hours for adverse drug reactions when the antifungal drug is given by the oral or parenteral route. When these dru are applied topically to the skin, the nurse inspects the area at the time of each application for localized skin reactions. When these dm i are administered vaginally, the nurse questions the patient regarding any discomfort or other sensations... [Pg.133]

Youenang Piemi, M.P., Korner, D., Benita, S. and Marty, J.P. (1999) Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. Journal of Controlled Release, 58, 177-187. [Pg.171]

TABLE 41.3 Topical Antifungal Drugs and Characteristic Courses of Treatment for Tinea Pedis... [Pg.492]

Nystatin (Mycostatin) is a polyene antifungal drug with a ring structure similar to that of amphotericin B and a mechanism of action identical to that of amphotericin B. Too toxic for systemic use, nystatin is limited to the topical treatment of superficial infections caused by C albicans. Infections commonly treated by this drug include oral candidiasis (thrush), mild esophageal candidiasis, and vaginitis. [Pg.598]

The antifungal drugs presently available fall into several categories systemic drugs (oral or parenteral) for systemic infections, oral drugs for mucocutaneous infections, and topical drugs for mucocutaneous infections. [Pg.1056]

Abstract Emulsions of silicone polymers having p-cyclodextrin units as lateral chains have been prepared and used for the encapsulation of the antifungal drug griseofulvin. Such technology enables the formulation of active substances that are not soluble in water as dosage fonns for topical administration. [Pg.163]

Nystatin, the earliest antifungal drug, is used today primarily by the oral route to treat gastrointestinal mycosis and topically for mucocutaneous candidiasis (SED-11, 576). Absorption from the gut is insufficient to produce systemic activity. [Pg.2591]

The therapeutic use of sodium propionate in topical antifungal preparations has largely been superseded by a new generation of antifungal drugs. A specification for sodium propionate is contained in the Food Chemicals Codex (FCC). The EINECS number for sodium propionate is 205-290-4. [Pg.700]

Nystatin was discovered in 1950 and exhibits the same mode of action as amphotericin B but tends to be of lower solubility, which has restricted its use to the treatment of topical infections. While nystatin was effective for the treatment of conditions such as oral and vaginal candidosis its use has been overtaken by the introduction of azole antifungal drugs. [Pg.50]

Haloprogin. 3-Iodo-2-propynyl 2,4,5-trichlorophenyl ether, C9H4Q3IO, is an almost insoluble antifungal for topical States. Haloprogin [777-11-7] was developed in 1963 and it is active against dermatophytes. The drug s effect against Candida sp. [Pg.255]

Superficial fungal infections can usually be treated with topical preparations, but systemic antifungal drugs can be necessary for nail and scalp infections, or if skin infection is extensive and unresponsive to topical therapy. [Pg.147]

Amorolflne is a novel topical antifungal drug. It has a similar action to terbinaflne affecting synthesis of fungal cell membrane ergosterol and is generally fungicidal. [Pg.149]

A summary of topical antifungal drugs is given in Table 8.3. [Pg.150]


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See also in sourсe #XX -- [ Pg.547 , Pg.550 ]

See also in sourсe #XX -- [ Pg.1118 ]




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