Antifatigue activity

Since UV absorbers cannot completely prevent the initiation reactions above, we felt that better antioxidants were necessary to obtain improved long-term photo-oxidative stability of polyolefins. We reasoned that stable radicals which scavenge radicals formed in the oxidative process might compensate for the imperfections of the absorbers. On the basis of the assumption that the diaryl nitroxyl radicals, rather than their parent diarylamines, are the active antifatigue species in rubber protection, we first attempted to obtain new stable nitroxyl radicals. 

DPA are excellent AO and HS in various rubbers and plastics, lubricating greases and oils [27], They have some antifatigue effect and provide no antiozonant protection [1], Their photostabilization activity is rather low. DPA may be used in radiation resistant polymer compositions for cable coatings in nuclear power plants [28]. Various 4,4 -disubstituted DPA contain a fert-alkyl (e.g. 1,1,3,3-tetramethylbutyl 9a, 1,1-dimethylethyl or their combinations), other alkyls or aralkylgroups (e.g. a,a-dimethylbenzyl, 9b) [1,3,24]. A tertiary amine 3-[(diphenylamino)methyl]-5-[(diphenylaminomethyl)thio]-l,3,4-thiadiazolidine-2 (14) was proposed as AO for rubbers [29],... 

Stabilizing activity is improved in mixtures of aromatic amines varying in their structures. This is due to different contributions to antioxidant, antifatigue or antiozonant effects. Combinations of DPA 9a with PD 11c, d, PNA with PD, ternary mixtures PD/DPA/PNA, PD lib with DHQ 16b or 16c, oligomeric 21 with 11 or 16 (R = NHCftHj), condensate 22 with lib, PT 20 with 9 or lib are examples of combinations effective in rubber protection. Mixtures containing... 

Licorice has shown distinct antifatigue and antistress activity, and in vivo studies have shown strong activity against cancerous tumors and some protection from the effects of radiation. Perhaps it is best known for its estrogenic effects, which make it a useful herb for menopause, and its antiulcer activity, making it an herb of choice for both stomach and duodenal ulceration. Because it stimulates expectoration and is powerfully healing for mucous membrane systems, it has a long history of use for upper respiratory infections. 

A similar pursuit was made by Kim and Lee [28] and by Upadhyay and Warrach [29], who found they could make considerable savings in test times with a procedure still sufficiently sensitive to detect the antifatigue cracking activities of some antidegradants. Good agreement with De Mattia crack growth behavior was reported. 

Rbi, a representative of the saponins derived from 20(S)-proto-panaxadiol (26) (Table I) reportedly exhibited central nervous system-depressant and antipsychotic activity, protection of stress ulcer, increase of gastrointestinal motility and weak anti-inflammatory action, while Rgi, the major saponin of 20( S)-protopanaxatriol (36) (Table II) showed weak central nervous system-stimulant action, antifatigue action and aggravation of stress ulcer (757, 752, 755, 164, 165, 166). Kaku etal. 167) on investigating the pharmacology of the major saponins, reported the... 

Reversal of sickling/crenation of erythrocytes Hepatoxic protection C.N.S, activity Cardiovascular activity Antifertility agents Stress protection/antifatigue effects... 

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