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Antibodies immunoglobulin classes

H, Devey ME Immunoglobulin class and subclass distribution of dextran-reactive antibodies in human reactors and non-reactors to clinical dex-tran. Allergy 1982 37 481-489. [Pg.97]

ANAb Anti-nuclear antibodies ANCA Anti-neutrophil cytoplasmic auto antibodies cANCA Cytoplasmic ANCA pANCA Perinuclear ANCA AND Anaphylactic degranulation ANF Atrial natriuretic factor ANP Atrial natriuretic peptide Anti-I-A, Anti-I-E Antibody against class II MHC molecule encoded by I-A locus, I-E locus, anti-lg Antibody against an immunoglobulin... [Pg.279]

Antibody classes In mammals, there are five classes of antibodies (also known as immunoglobulins IgG, IgA, IgM, IgE and IgD). Each immunoglobulin class differs in their heavy chain constant domains (see Fig. 1.2) and consequently in its biological properties. For immunoassays, two immuno-glubulin classes are of importance - IgG and IgM. [Pg.142]

Control slides of known reactivity should be run with each set of slides immunostained. Appropriate controls should include an irrelevant antibody of the same immunoglobulin class at an equivalent concentration. [Pg.220]

Beh, K. J. 1973. Distribution of brucella antibody among immunoglobulin classes and a low molecular weight antibody fraction in serum and whey of cattle. Res. Vet. Sci. 14, 381-384. [Pg.150]

Hammer, D. K., Kickhoefen, B. and Schmid, T. 1971. Detection of homocytotropic antibody associated with a unique immunoglobulin class in the bovine species. Eur. J. Immunol. 1, 249-257. [Pg.157]

Gearhart, P.J., Sigal, N.H., Klinman, N.R. (1975). Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell. Proc. Natl. Acad. Sci. USA 72, 1707-1711. [Pg.74]

Intrasplenic immunization is used for the production of hybridomas in situations where only very small quantities of the antigen are available. Typically, it lends itself extremely well to producing antibodies to proteins that have been purified by electrophoresis and subsequent blotting onto nitrocellulose. Antibodies produced by this route are always immunoglobulin class M as only one immunization is used. This method is covered by Animal Procedures legislation in most countries as it is an invasive surgical procedure and welfare issues must be addressed. [Pg.10]

There is no one procedure or combination of procedures that is applicable to all cases. The class of antibody to be purified has to be considered. Conventional procedures for the production of polyclonal antisera will generally result in immunoglobulin G, and procedures for the generation of monoclonal antisera may result in any of the immunoglobulin classes. Immunoglobulins from different species have broadly similar properties, but protein A, for example, will not bind all of the subclasses of human IgG, nor is it particularly effective in the purification of IgG from rat, sheep, or goat (2). Thus a certain amount of trial and error may be required to reach the best protocol for a particularly demanding application, but the methods described here should provide an adequate purity for most purposes. [Pg.217]

R16. Rothfield, N. F., and Stollar, B. D., The relation of immunoglobulin class, pattern of anti-nuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. J. Clin. Invest. 46, 1785-1794 (1967). [Pg.168]

Although the cellular and humoral response in experimental animals tends to be relatively uniform, it must be remembered that in man (and domestic animals) the immune responses can vary enormously. This is undoubtedly related to human genetic diversity - unlike the uniform genetic background of most experimental animals. These responses have been much studied in hydatid disease and (T. solium) cysticercosis. In the latter case, the frequency of different precipitation bands in serum immuno-electrophoresis (Fig. 11.8) and of the immunoglobulin classes (Table 11.4) show great variation between patients (226). Moreover, some patients show no humoral or cellular response whatsoever (226). Similarly, there is much variation in the immune responses to hydatid disease and, again, some patients show no detectable antibody (734). [Pg.298]

Fig. (14). Affinity pattern, agar diffusions (C and D), A=S. pneumoniae, B=S. mulans, and immunoglobulin class (Ab) of anti-S. mutans or anti-X pneumoniae antibodies (Ab), A[, G, M, globulins.. Fig. (14). Affinity pattern, agar diffusions (C and D), A=S. pneumoniae, B=S. mulans, and immunoglobulin class (Ab) of anti-S. mutans or anti-X pneumoniae antibodies (Ab), A[, G, M, globulins..
The sera contain antibodies of different immunoglobulin classes, toward which the conjugate reacts with different effectiveness. [Pg.436]


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See also in sourсe #XX -- [ Pg.521 ]

See also in sourсe #XX -- [ Pg.521 ]

See also in sourсe #XX -- [ Pg.29 , Pg.521 ]




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