Anti-nuclear antibodies

Immunological abnormalities were reported in 23 adults in Woburn, Massachusetts, who were exposed to contaminated well water and who were family members of children with leukemia (Byers et al. 1988). These immunological abnormalities, tested for 5 years after well closure, included persistent lymphocytosis, increased numbers of T-lymphocytes, and depressed helper suppressor T-cell ratio. Auto-antibodies, particularly anti-nuclear antibodies, were detected in 11 of 23 adults tested. This study is limited by the possible bias in identifying risk factors for immunological abnormalities in a small, nonpopulation-based group identified by leukemia types. Other limitations of this study are described in Section 2.2.2.8. A study of 356 residents of Tucson, Arizona, who were exposed to trichloroethylene (6-500 ppb) and other chemicals in well water drawn from the Santa Cmz aquifer found increased frequencies of 10 systemic lupus erythematosus symptoms, 5 (arthritis, Raynaud s phenomenon, malar rash, skin lesions related to sun exposure, seizure or convulsions) of which were statistically significant (Kilbum and Warshaw 1992). 

ANAb Anti-nuclear antibodies ANCA Anti-neutrophil cytoplasmic auto antibodies cANCA Cytoplasmic ANCA pANCA Perinuclear ANCA AND Anaphylactic degranulation ANF Atrial natriuretic factor ANP Atrial natriuretic peptide Anti-I-A, Anti-I-E Antibody against class II MHC molecule encoded by I-A locus, I-E locus, anti-lg Antibody against an immunoglobulin... 

L4. Lichtman, M. A., Vaughan, J. H., and Hames, G. G., The distribution of serum immunoglobulins, anti G globulins (rheumatoid factors) and anti nuclear antibodies in white and negro subjects in Evans County, Georgia. Arthritis Rheum. 10, 204-215 (1967). 

R16. Rothfield, N. F., and Stollar, B. D., The relation of immunoglobulin class, pattern of anti-nuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. J. Clin. Invest. 46, 1785-1794 (1967). 

Rheumatoid factor antibody, rheumatoid arthritis Anti-nuclear antibodies, systemic lupus erythematosus Platelet-associated IgG, idiopathic thrombocytopenia purpura (ITP) Blood typing and crossmatching Transplantation HLA antibodies... 

Ohsawa M, Takahashi K, Otsuka F (1988) Induction of anti-nuclear antibodies in mice orally exposed to cadmium at low concentrations. Clin Exp Immunol, 73 98-102. 

Administration of diphenylhydantoin via drinking water for 6 months) to genetically predisposed mice (C57BL/6-lpr/lpr strain) rather depressed the levels of anti-nuclear antibodies (ANA) (Bloksma et al, 1994). In another study (Okada et al., 2001), the effect of a 4-week exposure to diphenylhydantoin on KLH sensitization was studied. It was found that the drug caused an... 

Some immunological abnormalities were found in 23 adults in Wobum who were exposed to contaminated water and who were family members of children with leukemia. These immunological abnormalities, tested for 5 years after well closure, were persistent lymphocytosis, increased numbers of T lymphocytes, and depressed helper suppressor T cell ratio. A follow-up test 18 months later revealed reductions in lymphocyte counts, decreased numbers of suppressor T cells, and increased helper suppressor ratio. Auto-antibodies, particularly anti-nuclear antibodies, were detected in 48%... 

Fernandes, G., Yunis, E.J., Jose, D.G., and Good, R.A. (1973) Dietary Influence on Anti-Nuclear Antibodies and Cell-Mediated Immunity in NZB Mice, Int. Arch. Allergy Appl. Immunol. 44,770-782. 

Pusey CD, Bowman C, Morgan A, Weetman AP, Hartley B, Lockwood CM (1990) Kinetics and pathogenicity of autoantibodies induced by mercuric chloride in the Brown Norway rat. Clin Exp Med 81 76-82 Reeves AL (1983) The immunotoxicity of beryllium. In Gibson CG, Hubbard R, Parke DV (eds) Immunotoxicology. Academic, London, p 261 Robinson CJG, Abraham A A, Balazs T (1984) Induction of anti-nuclear antibodies by mercuric chloride in mice. Clin Exp Immunol 58 300-306 Robinson CJG, Balazs T, Egorov IK (1986) Mercuric chloride, gold sodium thio-malate, and D-penicillamine-induced anti-nuclear antibodies in mice. Toxcol Appl Pharmacol 86 159-169... 

Razavi, L. Use of fluorescein-labelled anti-nuclear antibodies in the study of chromosomal structure. In Nucleic acids in immunology, ed. by Plescia O. J. and Braun W., p. 248-270. Berlin-Heidelberg-New York Springer 1968. 

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