Catalytic antibodies pericyclic reactions

One aspect of antibody catalysis that tmly ignites the imagination of the chemical biologist is that these biocatalysts are not limited to reactions that have a natural enzymatic equivalent. The Diels-Alder reaction has immense synthetic utility however, this chemical transformation is extremely rare in nature. Furthermore, the reaction proceeds via an entropicaUy disfavored, highly organized pericyclic transition state (78). The programmability of a catalytic antibody has enabled the catalysis of the Diels-Alder reaction previously considered beyond the realm of possibility with a protein (79-84). 

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