Catalytic antibodies proximity effects

An alternate complementary approach toward catalytic antibody generation that could overcome the entropic disadvantage of preorganization of the amine cofactor with the Ab catalyst was investigated. A phosphinate (Scheme 5.64) was designed to mimic the expected transition state for the addition of a pheny-lacetone derived enolate to the carbonyl of benzaldehyde. An Ab raised against this hapten was expected to catalyze the aldol condensation of benzylacetone and benzaldehyde by both proximity and electrostatic effects. However, while... 

Other approaches have been developed to generate catalytic antibodies including covalent catalysis, proximity effects, and general acid-base catalysis [7]. In addition, strategies have been developed to directly select immu-... 

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