Sigmatropic rearrangements catalytic antibodies

Further examples of catalytic antibodies that are presumed to control rotational entropy are AZ-28, which catalyses an oxy-Cope [3.3]-sigmatropic rearrangement (Appendix entry 13.1) (Braisted and Schultz, 1994 Ulrich et al, 1996) and 2E4, which catalyses a peptide bond isomerization (Appendix entry 13.3) (Gibbs et al., 1992b Liotta et al., 1995). Perhaps the area for the greatest opportunity for abzymes to achieve control of rotational entropy is in the area of cationic cyclization reactions (Li et al., 1997). The achievements of the Lerner group in this area (Appendix entries 15.1-15.4) will be discussed later in this article (Section 6). 

Catalytic antibodies have been obtained for sigmatropic rearrangements, as first demonstrated for the biotransformation of chorismate to prephenate by two chorismate mutase antibodies developed in parallel by Hilvert et al. and Schultz et al. [76]. The Schultz group also described catalysis of an oxy-Cope rearrangement [77]. Schultz et al. and Hilvert et al. have prepared catalytic antibodies for concerted eUminations of aminoxide 53 and selenoxide 54 from immunization... 

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