Cocaine, catalytic antibodies against

Basmadjian G., Singh S., Sastrodjojo B. et al. Generation of polyclonal catalytic antibodies against cocaine using transition state analogs of cocaine conjugated to diphtheria toxoid. Chem. Pharm. Bull. 43 1902, 1995. 

Mets B., Winger G., Cabrera C. et al. A catalytic antibody against cocaine prevents cocaine s reinforcing and toxic effects in rats. Proc. Natl. Acad. Sci. U.S.A. 95 10176, 1998. 

As another minor point, the use of catalytic antibodies with esterase activity could theoretically lead to autoimmunity against endogenous enzymes. This problem could be partially overcome if Fab fragments were used, or perhaps completely overcome if humanized antibodies or their fragments w ere used. Also, it is not currently known if endogenous ligands will be substrates for these catalytic enzymes this could potentially decrease the effective rate for cocaine metabolism or lead to other medical problems. 

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