Antibiotics against Staphylococcus aureus

A. Shahverdi, A. Fakhimi, H. Shahverdi, S. Minaian Synthesis and Effect of Silver Nanoparticles on the Antibacterial Activity of Different Antibiotics Against Staphylococcus Aureus and Escherichia Coli, ""Nanomedicine Nanotechnology, Biology and Medicine . 2007, v. 3, iss. 2,168-171. 

Moghaddam KM, Iranshahi M, Yazdi MC, Shahverdi AR (2009) The combination effect of cur-cumin with different antibiotics against Staphylococcus aureus. Int J Green Pharm 3 141-143 Morrissey IP, Osbourn AE (1999) Fungal resistance to plant antibiotics as a mechanism of pathogenesis. Microbiol Mol Biol Rev 63 708-724... 

Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages , Antimicrob Agents Chemother, 50,841-851. 

Purification of Antibiotic 66-40 — Dissolve 28 g of crude Antibiotic 66-40 in 100 ml of distilled water and charge to an anion exchange adsorption column (Dowex 1 X2) in the hydroxyl form. Slurry 2,000 g of the resin in water in to a column 2yj in diameter and 36 "high. Elute the column with distilled water at a rate of about 23 ml/min collecting 100 ml fractions and monitor with a conductivity meter and by disc testing against Staphylococcus aureus. 

Oral, narrow-spectrum antibiotic therapy with activity against Staphylococcus aureus and streptococcal species. Include coverage for MRSA (HA- or CA-MRSA) according to patient history and resistance patterns in the area. 

There was some antibiotic activity against Staphylococcus aureus. Streptococcus jecalis. Bacillus subtilis, Escherichia coli and Mycobacterium phlei (28). 

Aeroplysinin-1 (852), a metabolite of marine organisms, shows antibiotic activity against Staphylococcus aureus and antileukemia activity against L-1210. This metabolite was synthesized by Pb(OAc)4-mediated phenolic oxidation as a key step. Here, 3,5-dibromo-2-hydroxy-4-methoxyphenylacetonitrile (853) was oxidized with excess of Pb(OAc)4 in AcOH to give in 35% yield the desired cyclohexa-2,4-dienone 854, which was converted to the target molecule in 2 steps. 

The new compounds (203-205) and the derivatives 206-208 were assayed for antimicrobial activity. Compounds 203-205 showed antibiotic activity against B. subtilis with a MICs of 12-14, 35-39 and 25 xg/ml, respectively 203 was also active against Staphylococcus aureus (MIC 40-50 xg/ml). These results suggest that the antibiotic activity may be associated with the presence of free hydroxyl groups in ring A compound... 

Ibberine. Metabolite from Haplophyllum tuberculatum (Rutaceae) (aerial parts) with antibiotic activity against Staphylococcus aureus and Escherichia colt... 

The minimum inhibitory concentration of tryptanthrin against 17 fungal strains, including Trichophyton mentagrophytes and T. rubrum have been investigated 206). The antibiotic activity of this compound depends on the composition of the agar medium [cf. 183) for further details]. Quinazomycin is active against Staphylococcus aureus 113). 

Actinorhodin (ACT) belongs to a class of aromatic antibiotics (benzoisochromane-quinones, BIQs), and is a red pigment produced by 5. coelicolor A3(2), with weak bacteriostatic activity against Staphylococcus aureus [182]. The BIQ antibiotics showed a trans confguration with respect to the C-3 and C-15 chiral centers (35,15R or 3R,155). ACT represents the former type the opposite stereochemistty is exemplified by granaticin (GRA) produced by Streptomyces violaceoruber (Figure 6.38) [183]. 

The azirinomycin (12), 3-methyl-2H-azirine-2-carboxylic acid, was isolated from a strain of Streptomyces aureus. Its methyl ester (13) exhibited broad spectrum antibiotic activity in vitro against both Gram-positive and Gram-negative bacteria [33, 34]. The carboxylic acid (12) is most active against Staphylococcus aureus followed by Proteus vulgaris. Bacillus subtilis, and Streptococcus faecalis. In contrast, the methyl ester shows its lowest activities against one of the Staphylococcus aureus cultures and Streptococcus faecalis. 

Aiyegoro OA, Okoh Al (2009) Use of bioactive plant products in combination with standard antibiotics implications in antimicrobial chemotherapy. J Med Plant Res 3 1147-1152 Akroum S, Bendjeddou D, SattaD LK (2009) Antibacterial activity and acute toxicity effect of flavonoids extracted from Mentha longifolia. Am-Euras J Sd Res 4 93-96 Alvarez MA, Debattista NB, Pappano NB (2006) Syneigjsm of flavonoids with bacteriostatic action against Staphylococcus aureus ATCC 25 923 and Escherichia coli ATCC 25 922. Biocell 30 39-42... 

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