Anti-inflammatory and antiallergic effects

The anti-inflammatory and antiallergic effects of aromoline were evaluated via the measurement of antigen-induced histamine release from leukocytes, and it was found that the alkaloid inhibited antigen-induced histamine release [180]. 

Adrenal insufficiency, previously treated with extracts of adrenal cortex, is now treated by the administration of pure A.C. High doses reveal other pharmacological properties, especially anti-inflammatory and antiallergic effects. This discovery led to the development of highly active synthetic derivatives, which are now us to treat rheumatism, asthma, allergies, eczema, etc., e.g. prednisone (see Prednisolone), Dexamethasone (see) and Ttiamdnolone (see). 

Baicalein, baicalin, wogonin, skullcapflavone n, and 2, 5,5, 7-tetrahydroxy-6, 8-di-methoxyflavone have anti-inflammatory and antiallergic effects in animals skullcapflavone II also exhibited cytotoxic effects on L1210 cells (jiangsu). ... 

The very small amount of steroid that reaches the bloodstream from a topically administered drug can at least in theory cause some of the typical corticoid side-effects. This has occasioned research on corticoids that contain weak links that will lead to deactivation of the steroid by serum enzymes. The drug fluticasone (32-6) acts as a typical anti-inflammatory and antiallergic corticoid even though the side chain on ring D consists of a thioamide instead of a 2-hydroxyacetyl function. That thioamide provides the weak link that causes the drug to be destroyed by serum enzymes. As a result, fluticasone powder is used extensively in inhalers for treating asthma. 

Listed in Li Shi-Zhen s Ben Cao Gang Mu (ca. 1590) as one of the herbs for removing facial dark spots as well as having antipruritic properties, fangfeng is used in skin care products (creams, lotions, bath preparations, and antiallergic ointments) and in hair tonics for these properties and for its anti-inflammatory and whitening (tyrosinase inhibitory) effects. 

Mentha piperita subsp. citrata Briq. -horteia Tranquilizer Branch (infusion, ingested) Caboclos [57] Essential oils [138,139] flavonoid glycosides [140,141] menthol [142] menthofurolactone [143,144] pyridine-derivatives [145] mintlactone [146] flavones [147] triterpenes [148] terpenoids [149] sesquiterpenic hydrocarbons [150] menthofuran [151,152], Antimicrobial and antioxidant activities [138,265] antiallergic effect [140] anti-nociceptive and anti-inflammatory effects [266]... 

The effect of helminth infections on allergic-type diseases has prompted a search for helminth-derived fectors with therapeutic potential. Cystatin is a filarial-derived molecule with antiallergic and anti-inflammatory properties. Treatment with cystatin protects mice from DSS colitis and lung hypersensitivity responses to OVA allergen challenge. Cystatin induces macrophages to make ILIO, which could mediate this protection. 

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