Systemic lupus erythematosus anti-nuclear antibodies

Immunological abnormalities were reported in 23 adults in Woburn, Massachusetts, who were exposed to contaminated well water and who were family members of children with leukemia (Byers et al. 1988). These immunological abnormalities, tested for 5 years after well closure, included persistent lymphocytosis, increased numbers of T-lymphocytes, and depressed helper suppressor T-cell ratio. Auto-antibodies, particularly anti-nuclear antibodies, were detected in 11 of 23 adults tested. This study is limited by the possible bias in identifying risk factors for immunological abnormalities in a small, nonpopulation-based group identified by leukemia types. Other limitations of this study are described in Section 2.2.2.8. A study of 356 residents of Tucson, Arizona, who were exposed to trichloroethylene (6-500 ppb) and other chemicals in well water drawn from the Santa Cmz aquifer found increased frequencies of 10 systemic lupus erythematosus symptoms, 5 (arthritis, Raynaud s phenomenon, malar rash, skin lesions related to sun exposure, seizure or convulsions) of which were statistically significant (Kilbum and Warshaw 1992). 

R16. Rothfield, N. F., and Stollar, B. D., The relation of immunoglobulin class, pattern of anti-nuclear antibody, and complement-fixing antibodies to DNA in sera from patients with systemic lupus erythematosus. J. Clin. Invest. 46, 1785-1794 (1967). 

Rheumatoid factor antibody, rheumatoid arthritis Anti-nuclear antibodies, systemic lupus erythematosus Platelet-associated IgG, idiopathic thrombocytopenia purpura (ITP) Blood typing and crossmatching Transplantation HLA antibodies... 

Systemic lupus erythematosus (SLE). A chronic, remitting-relapsing inflammatory autoimmune disease affecting multiple organ systems, such as the skin, joints, serosal membranes, kidneys, blood cells, and central nervous system. The disease is very heterogeneous in clinical expression and serological factors. Autoantibodies directed against nuclear components ( - antinuclear antibodies) are typically detected. Anti-dsDNA, anti-Sm, and antiphospholipid antibodies are used as classification criteria. 

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