Anti juvenile hormone agents

Two of the better known "anti-juvenile "Hormone" agents, preco-cenes (9) and fluoromevalonate (10) are inhibitors of JH biosynthesis. The mode of action of fluoromevalonate at the molecular level is unknown. Elucidation of the mode of action of precocenes indicates that these plant chromene derivatives reach the site of JH biosynthesis, the corpora allata (CA), where they undergo a lethal epoxidation leading to extensive macromolecular alkylation and ultimately cause cell death (11, 12). Bioactivation of precocenes to the highly reactive precocene epoxide (13) in the corpora allata is almost certainly catalyzed by methyl farnesoate (MF) epoxidase (14), a cytochrome P-450 sonooxygenase (15) tdtich is the last enzyme of the JH biosynthetic pathway (at least in locusts and cockroaches). 

In addition. Connat and Ncpa (1990) examined various anti-juvenile hormone agents on the fecundity of the female tick Omithndoms mouhato and demonstrated that 500 pg of PBO applied topically induced rapid death. 

Staal, G. B. 1986. Anti Juvenile Hormone Agents. In Annual Review of Entomology, Vol.31, Mittler, T. E., Radovsky, F. J., and Resh, V. H., eds. pp.391-429 Palo Alto, Annual Reviews Inc. 

Other chemicals evaluated but not yet adopted commercially include organophosphorus compounds, triphenyltin compounds, quaternary ammonium salts, imidazoles, benzimidazoles, carbamates and the precocene anti-juvenile hormones [517]. Although none of the above has found use as an insect-resist agent, several have been used as antimicrobial agents for textiles. 

No prediction can be made as yet on the future role of anti-juvenile hormones in insect control. However, the results obtained hitherto demonstrate the possibility of developing anti-insect agents acting to disrupt rather than mimic endocrine function. 

Juvenile Hormone Analogs and Anti-JuvenUe Hormone Agents for Insect Control... 

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