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Agent anti-inflammatory

The anti-inflammatory agent Oxapro2in, 2-(4,5-diphenyl-2-oxa2ole)propionic acid mono aluminum and dihydroxyalurninum salts, is made by reaction of the sodium salt with aluminum sulfate under controlled conditions (96). Again, the aluminum salts of many carboxylic acid based dmgs are less irritating, ulcerous, and/or toxic, and have a more pleasant taste than their parent acids. [Pg.144]

This reaction has recently been exploited for the synthesis of 2,3-diarylthiophenes. Thus, P-chloro-a,p-unsaturated aldehyde 19 underwent reaction with ethylthioglycolate to produce 20. The production of 20 by this method enabled the synthesis of a number of derivatives for investigations of their use as anti-inflammatory agents. [Pg.187]

A CSP based on the adsorption of a chiral anthrylamine on porous graphitic carbon successfully resolved the enantiomers of tropic acid derivatives and anti-inflammatory agents in SFC [65]. The carbon-based CSP produced superior results when compared to an analogous silica-based CSP. Occasional washing of the column was necessary to remove highly retained substances. [Pg.310]

Show how ou might prepare the anti-inflammatory agent ibuprofen starting from isobutylbenzene. More than one step is needed. [Pg.780]

Lin K-C, Castro AC (1998) Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents. Curr Opin Chem Biol 2 453—457... [Pg.147]

Melanocortin peptides are potent anti-inflammatory agents displaying beneficial effects in diseases ranging from cardiovascular to arthritis to obesity to name a few. Within an inflammatory context, they have the ability to switch off early production of cytokines and at later stages they increase levels of anti-inflammatory proteins that lead to the resolution of the host inflammatory response potentially restoring homeostasis to the tissue. They could eventually be viewed as an alternative to glucocorticoids, as their mode of action often resembles that seen... [Pg.756]

Chamomile Matricaria chamomilla As a tea for gastrointestinal disturbances, as a sedative, and as an anti-inflammatory agent Fbssible contact dermatitis and, in rare instances, anaphylaxis Chamomile is a member of the ragweed family and those allergic to ragweed should not take the herb. [Pg.659]

Aryl 2-Acetamido-2-deoxy-(J-D-glucopyranosides—Potential Anti-inflammatory agents, S. A. Barker, R. G. Plevey, R. G. Simmonds, and M. Stacey, Tetrahedron, Suppl. 8 (Part II) (1966) 611-619. [Pg.38]

The 4-thiazolidinyl phosphonates 143 (Scheme 44) are known for their therapeutical properties, in particular as anti-inflammatory agents [5,89]. Their asymmetric synthesis by hydrophosphonylation of 3-thiazolines has been described using various chiral auxiliaries chiral phosphites such as (2S,4i )-2H-2-oxo-5,5-dimethyl-4-phenyl-l,3,2-dioxaphosphorinane (de = 2-8%) [90] or BINOL-phos-phite (de = 65-90%) [91] and also chiral catalyst such as titanium or lanthanide chiral complexes (ee = 29-98%) [92]. Hydrophosphonylation of C2-chiral3-thi-azolines has also been performed (de = 32-38%) [93]. [Pg.191]

Yamashita, E., Anti-inflammatory agent, Japanese Patent 07300421 [in Japanese], 1995. [Pg.424]

Polansky, J. and Weinreb, B. (1984). Anti-inflammatory agents steroids as anti-inflammatory agpnts. In Pharmacology of the Eye (ed. M.L. Sears) pp. 459-538. Springer Verl, Berlin. Rao, N., Romero, J., Fernandez, M. and Marak, G.E. (1986). Effect of iron chelation on severity of occular inflammation in an animal model. Arch. Ophthalmol. 104, 1369-1371. [Pg.141]

Ebselen is a seleno-oiganic that mimics glutathione peroxidase and inhibits iron-stimulated lipid peroxidation. It significandy reduced both inferct size and oedema progression in the middle cerebral artery exclusion (MCAO) focal model of stroke in tats (Matsui et al. 1990). Ebselen has also been shown to be an effective anti-inflammatory agent in a H202-dependent inflammation model in tats (Parnham 1991). [Pg.272]

Tachykinins, 43 (2005) 50 Tetrahydroisoquinolines, B-adrenomimetic activity, 18 (1981) 45 Tetrazoles, 17 (1980) 151 Thalidomide as anti-inflammatory agent,... [Pg.391]


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