Anti-inflammatory agents penicillamine

Having demonstrated an increase in anti-inflammatory activity for the Cu complexes of anthranilic acid and 3,S-dips as well as their safe use it was decided to test the hypothesis that Cu complexes of the clinically used anti-arthritic drugs might be more effective as anti-inflammatory agents than the parent drugs. For this purpose, Cu complexes were prepared using acetylsalicylic acid (aspirin) (12), 2-[3-(trifluoromethyl)phenyl]aminonicotinic acid (niflumic acid, 13) D-penicillamine (D-pen) (14), l-phenyl-5-aminotetrazole (fenamole, 15) and salicylic acid (16). 

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