Targeted anti-inflammatory agents

Figure 25 Targeted anti-inflammatory agents and indomethacin.

Anti-inflammatory agents (e.g., colon-, kidney-, or liver-targeted delivery) [255a] [261] [272] ... 

At the start of this project, we chose a-arylpropionic acids as the target molecules, because their S-isomers are well established anti-inflammatory agents. When one plans to prepare this class of compounds via an asymmetric decarboxylation reaction, taking advantage of the hydrophobic reaction site of an enzyme, the starting material should be a disubstituted malonic acid having an aryl group on its a-position. 

E. J. F. Franssen, R. W. Jansen, M. Vaalburg, and D. K. F. Meijer, Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules, Biochem. Pharmacol. 45 1215-1226 (1993). 

Therefore, there are different targets to attack the inflammatory process. Due to this, the study of the anti-inflammatory activity by the PPGs has been studied following different experimental models, trying to justify their mechanism of action as anti-inflammatory agents. 

---