The Anti-diabetic Potential of Vanadium Compounds

historical development of the potential of vanadium compounds in the treatment of diabetes  

modern vanadium compounds which are active in vitro and in vivo,  

speciation and distribution of vanadium under in vivo conditions  

Lacking insulin or insulin response = Accumulation of ketonic bodies 

Left two representatives of two groups of orally applied anti-diabetic drugs. Compound 1 derives from sulfonylurea and 2 from thiazolidinedione. Right schematic drawing of the hormone insulin. The active form, a monomer (shown), consists of two peptide chains which are hnked by two disulfide bridges. Chain A contains an additional disulfide hnk. 

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