Anti-allergic drug

Varney VA, Gaga M, Frew AJ, Eber VR, et al. 1991. Usefulness of immunotherapy in patients with severe summer hayfever uncontrolled by anti-allergic drugs. Br Med J. 302 265-269. 

Oyama Y, Shishibori T, Yamashita K, Naya T, Nakagiri S, Maeta H, Kobayashi R. 1997. Two distinct anti-allergic drugs, amlexanox and cromolyn, bind to the same kinds of calcium binding proteins, except calmodulin, in bovine lung extract. Biochem Biophys Res Commun 240(2) 341-347. 

Shishibori T, Oyama Y, Matsushita O, Yamashita K, Furuichi H, Okabe A, Maeta H, Hata Y, Kobayashi R. 1999. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem J 338 ( Pt 3) 583-589. 

Gibbs BF, Vollrath IB, Albrecht C, Amon U, Wolff HH. Inhibition of interleukin-4 and interleukin-13 release from immunologically activated human basophils due to the actions of anti-allergic drugs. Naunyn Schmiedebergs Arch Pharmacol 1998 357(5) 573-8. 

Nishida T, Kusakai Y, Ogoshi R. [Four cases of cystitis induced by the anti-allergic drug tranilast.] Hinyokika Kiyo 1985 31(10) 1813-17. 

Church, M.K. and Hiroi, J. (1987). Inhibition of IgE-dependent H release from human dispersed lung mast cells by anti-allergic drugs and salbutamol. Br. J. Pharmacol. 90, 421-429. 

Okada, M., Itoh, H., Hatake) ma, T., Tokumitsu, H., Sc Kobayashi, R. (2003). Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. TheBiochemicaljoumah 374, 433-441. 

Hasegawa T, Takagi K, Nadai M, Ogura Y, Nabeshima T. Kinetic interaction between tiieo-phylline and a newly developed anti-allergic drug, pemirolast potassium. EurJ Clin Phamacol 99A) 46, 55-8. 

All that is left is a carbon atom and this is one of very few ways to make carbon atoms chemically. The carbon atoms have remarkable reactions and these have been studied briefly, but the hazardous preparation of the starting materials discourages too much research. However, you will see in the next chapter that 1-amino tetrazole is a useful starting material for making an anti-allergic drug. 

Antibacterial agents, vaccines and non-steroidal anti-inflammatory drugs (NSAIDs) may all lead to anaphylactic shock if the patient is allergic to these products. 

If patients are on anti-allergic and anti-asthmatic drugs, herbal formulas that stimulate the Qi and excite the Yang should not be used. Formulas that contain sweet and sour herbs that can slow down the Qi movement should also be avoided. 

Special interest in the prostaglandins has focused on pain of inflammation and allergic responses. The medical significance is easy to see. Five million Americans have rheumatoid arthritis, an inflammatory disease. Bronchial asthma and other allergic diseases are equally important. Our most common medicine is aspirin, an anti-inflammatory drug. Both the inflammatory response and the immune response are normal parts of the defense mechanisms of the body, but both are potentially harmful, and it is their regulation that is probably faulty in rheumatoid arthritis and asthma. Overproduction of prostaglandins may be a cause of menstrual cramps.308... 

Corticosteroids—a group of anti-inflammatory drugs similar to the natural corticosteroid hormones produced by the cortex of the adrenal glands. The disorders that often improve upon corticosteroid treatment include asthma, allergic rhinitis, eczema, and rheumatoid arthritis. 

Various nonsteroidal anti-inflammatory drugs (NSAIDs) have been studied for potential clinical use in allergic conjunctivitis. Specifically, ketorolac tromethamine 0.5% has been found to be beneficial in treating SAC and is currently the only NSAID approved for topical treatment of SAC. 

A good example of a drug made from aminotetrazole is Merrell Dow s anti-allergic agent MSD 427. You will notice that the drug 99 is actually the stable anion of the tetrazole. It makes sense to disconnect the aminotetrazole immediately to reveal the /V-formyl derivative 100 of o-amino-benzoic acid (anthranilic acid) 101.11... 

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