Anthrax lethal toxin

Anthrax lethal factor metalloproteinase (Table 1, entry 7) Anthrax lethal factor metalloproteinase is an integral component of the tripartite anthrax lethal toxin and is required for the onset and progression of anthrax. About 300 scaffolds were selected for an NMR-based assay leading to the carboxylic acid fragment 31 [42]. Subsequent synthetic elaboration led to nanomolar inhibitors such as 32. 

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