Valeryl chloride

Valeraldehyde, p28 Valeric acid, p38 Valeronitrile, p35 Valeryl chloride, p45 Vanillic acid, hi43 Vanillin, hl42 Vanillyl alcohol, hl45 Veratraldehyde, d492 Veratric acid, d496 Veratrole, d493 Veronal, d330... 

TRIMETHYL-3-OXOVALERYL CHLORIDE (Valeryl chloride, 2,2,4-trimethyl-3-oxo-)... 

A recent halogen-free benzofuran that shares many structural features with its predecessor shows activity in controlling arrythmias. The synthesis starts with an unusual scheme for building the furan ring. Reaction of the benzyl bromide (2-1) with triphenylphosphine leads to phosphonium salt (2-2). Treatment of the salt with valeryl chloride in the presence of pyridine results in acylation on the now highly activated benzylic carbon (2-3). That product cyclizes to the benzofuran (2-4) on heating with expulsion of triphenylphosphine. Friedel-Crafts acylation of (2-4) with anisoyl chloride in the presence of stannic chloride proceeds on the... 

Carbomethoxybenzaldehyde, 30, 100 5-Carbomethoxy valeryl chloride, 38, 39 Carbon disulfide, 30, 57 39, 8, 78 Carbonic acid, trithio-, bis(carboxy-methyl) ester, 39, 77 Carbonic-carboxylic anhydrides, 37, 21 Carbon monoxide, 34, 14 Carbon oxysulfide, 32, 103 Carbon tetrachloride, 32, 27 37, 8 Carbonylation, of pyrogallol-1,3-dimethyl ether with hexamethylenetetramine, 31, 92 of pyrrole with dimethylformamide,... 

Furyl)valeryl chloride gave the expected ketone (332) in 60% yield.741... 

A selection of the results obtained with 4,4 -azobis(4-cyano valeryl chloride) and some polyethylene glycols are listed in Table 4.2. 

In a similar way as has been described for syntheses of type al, the majority of examples of type b involve polycondensation of a,ea bifunctional, small molecule reaction partners. Some examples are the reaction of AIBN or AIBN derivatives with 1,4-cyclohexane bismethyl diamine78), 1,2-ethylene diamine78), 1,6-hexamethylene diamine 78-80 , bisphenol A 78,81 and mono-, di- and tetraethylene glycol 55-64 . In almost all case using the AIBN derivative 4,4 -azobis(4-cyano valeryl chloride), an interfacial polymerization was employed. These polymeric azo compounds could be used as initiators for radical block copolymerizations. 

Uracil, p268 5-Ureidohydantoin, a77 Urethane, e91 Valeraldehyde, p27 Valeric acid, p36 y-Valerolactone, p40 Valerone, d531 Valeronitrile, p33 Valeryl chloride, p44 Valinols, a213, a214... 

Sodium hydride (97%), triethyl phosphite (99%), a,a dibromo-p-xylene (97%), 4-hydroxy-3-methylbenzaldehyde (97%), 3-ethoxy-4-hydroxybenzaldehyde (99%), vanillin (99%), and valeryl chloride (98%), were supplied by Aldrich Chemical Co. and were used without further purification 4-hydroxybenzaldehyde (96%, Aldrich) was resublimed prior to use. The add chlorides were supplied by Aldrich Chemical Co. and, with the exception of sebacoyl chloride (99+%), were fractionally distilled at reduced pressure through a 6-inch Vigreux column prior to use pimeloyl chloride 95-6°C at 1.1 torr, suberoyl 114-16°C at 2.2 torr, azelaoyl 104-6°C at 0.35 torr. Dibromoalkanes from Aldrich Chemical were fractionally distilled prior to use 1,7-dibromoheptane 111-114°C at 1.4 torr, 1,9-dibromononane 135-137°C at 2.7 torr, 1,11-dibromoundecane 129-131 °C at 0.85 torr. Tetrabutylammonium iodide (98%) was supplied by Aldrich. Reagent grade solvents were obtained from Fisher Scientific. 

Ester Model Compounds and Polv(esters). The synthesis and characterization of the ester materials was described previously (Mates, T.E. Ober, C.K. J. Polvm. Sci. Lett., to be published. The model compounds were prepared by reacting the bisphenols with an excess of valeryl chloride to make the poly(esters), the bisphenols were reacted with stoichiometric amounts of alkyl diacid chlorides as shown in Scheme 1. 

Trihydroxyvalerophenone. Use 15 g (0.12mol) of phloroglucinol, 48g (0.56 mol) of anhydrous powdered aluminium chloride and 14.4 g (0.12mol) of valeryl chloride (Expt 5.138) with the same volumes of nitrobenzene and carbon disulphide and under the conditions described for phloroisobutyro-phenone. The yield of hydrated product, m.p. 88-90 °C (m.p. 152-154°C, anhydrous), is 11.5 g (42%). 

Plicnyl valeryl chloride - pheno-keto-lieptainethy-... 

Ethyl valerimidate Sodium cyanide Triethylamine Valeryl chloride Tributyltin azide... 

A solution containing 5.0 mg of N-trifluoroacetyladriamycin dissolved in 0.5 ml of anhydrous pyridine was treated with 18 microliters of valeryl chloride, which was added in small portions over a two-day period. The reaction was monitored by thin layer chromatography and when the presence of N-trifluoroacetyladriamycin could no longer be observed, the reaction mixture was diluted with 10 ml of chloroform. The chloroform solution was extracted three times with pH 4 buffer and once with pH 7 buffer. The dried chloroform solution was then evaporated under reduced pressure, and the residue was purified by preparative thin layer chromatography on silica gel G with chloroform methanol water (120 20 1 by volume) as the solvent system. The major orange-colored band was removed and washed free of silica gel with a mixture of methanol and ethyl acetate. Upon evaporation of the methanol and ethyl acetate, 2.19 mg of N-trifluoroacetyladriamycin-14-valerate was obtained. This material was idential by spectral and chromatographic comparison with samples of N-trifluoroacetyladriamycin-14-valerate prepared by earlier described methods. 

Transfer the supernatant from step 2 by cannula to the copper(l) cyanide/ lithium bromide solution. Once the transfer is complete, add valeryl chloride (1.4 g, 11.6 mmol) and allow the reaction mixture to warm to room temperature as it stirs overnight. 

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