Estradiol valerate + norethisterone

Table 1 The numbers of adverse events in 3 successive years in patients taking estradiol valerate + norethisterone (5)...

Perry W, Wiseman RA, Cullen NM. Combined oral estradiol valerate-norethisterone treatment over three years in postmenopausal women. 1. Clinical aspects and endometrial histology. Gynecol Endocrinol 1998 12(2) 109-22. 

Jiang, L.-X. Wang, Z.-J. Matlin, S.A. HPLC analysis of ipjectable contraceptive preparation containing norethisterone enanthate and estradiol valerate. J.Liq.Chromatogr., 1990, 13, 3473-3479 [simultaneous benzyl benzoate, estradiol valerate, norethisterone enanthate column temp 15]... 

Koninckx PR, Spielmann D. A comparative 2-year study of the effects of sequential regimens of 1 mg 17-beta-estradiol and trimegestone with a regimen containing estradiol valerate and norethisterone on the bleeding profile and endometrial safety in postmenopausal women. Gynecol Endocrinol 2005 21 82-9. 

Of 206 postmenopausal women who took the oral combination of estradiol valerate plus norethisterone (5) eight withdrew because of bleeding during year 1 during years 2 and 3 there were no withdrawals because of bleeding. By the end of year 3, 133 patients had completed the study. There were serious adverse effects in 24, but there was no definite relation to therapy. The numbers of adverse events reported each year by the patients who completed the study are shown in Table 1. The authors concluded that this combination was effective in the majority of patients and was well tolerated. 

L.-X, Jiang, Z. J. Wang, and S. A. Matlin, HPLC analysis of injectable contraceptive preparation containing norethisterone en-anthate and estradiol valerate, J. Liquid Chromatogr., 73 3473... 

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