Animal experimental procedure

All animal experimental procedures (including handling, housing, husbandry, blood collection, and drug treatment) must be conducted in accordance with national and institutional guidelines for the care and use of laboratory animals. 

Stephens ML, Mendoza P, Hamilton T, Weaver A (1998) Unrelieved pain and distress in animals an analysis of USDA data on experimental procedures. J Appl Anim Welf Sci 1 15-26... 

This section is devoted to the definition and comparison of the three nonrodent animal models (dog, ferret, and monkey) in terms of experimental procedures, environmental and dietary requirements, as well as advantages and disadvantages of use in safety assessment testing. 

The volume of solution injected, up to 2 ml, appeared in itself to be unimportant in producing lethality in mice although most of the subjects had obvious discomfort for 30 minutes or so. Normal saline in doses of 1.0-2.0 ml produced a comatose condition in all animals at the highest dose, 2 of 6 subjects did not survive the experimental procedure. 

In the United Kingdom, by the time of the adoption of the Directive, the authorities had already introduced legislation for the control of animal experimentation in the form of the Animal and Scientific Procedures Act 1986. Its content and coverage was already relatively comprehensive of the requirements set out under the Directive, and so relatively little needed to be done to bring the UK law in line with the European provisions. 

There exists no scientific basis for the use of animal studies to predict the antitumor effect of a compound however, a fairly good correlation has been shown between the antitumor effects seen in animal studies and those observed in the clinical setting [210], In order to produce an animal model which possesses the requirements listed above, the variable factors present in the experimental procedure, and the characteristics of the tumor and animals must be addressed. 

The equipment and experimental procedures used to generate transgenic animals are accurately described in laboratory handbooks by Hogan et al. (1986) and Wassarman and De Pamphilis (1993). 

Harmonization of standards and evaluation procedures in the area of consumer safety will strengthen public confidence in the safety of food stuffs of animal origin, decrease trade barriers for food commodities and veterinary medicinal products, and help to reduce the amount of animal experimentation. In any... 

Experimental procedure whereby an animal learns to receive brief, low intensity electrical stimuli to subcortical regions of the brain that elicit a reward. 

All the experimental procedures were carried out in accordance with the European Community Council Directive on 24 November, 1986 (86/609/ EEC), included in the D.M. 116/1992 of the Italian Ministry of Health. All efforts were made to minimize the number of animals used and their suffering. 

All animals made a full and uneventful recovery from the experimental procedure and no evidence for drug or procedural related adverse reactions was obtained. Mucosal tissue biopsies showed no apparent damage at the microscopic level. 

The conclusions that can be drawn from the experimental evidence reported above can be summarized as follows. First, laboratory mice maintained in a conventional animal house display, in comparison with mice kept in a protected low stress environment, display distinct humoral and immunity characteristics of exposure to stress that accompany significant differences in spontaneous tumor metastasis handling the animals for experimental procedures... 

Investigations aiming to study the effects of stress on metastasis in laboratory mice, should focus on a careful control of the stress resulting from housing and handling the animals for the experimental procedures. 

In addition to the theoretical implications of this research, there is also a practical advantage to the use of the general experimental procedures described above. Studies which examine the effects of a treatment on memory processing are perhaps best suited to do so if the treatment is administered shortly after training. This design assures that all animals... 

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