Sodium citrate anhydrous

See Section 17 for anhydrous sodium citrate animal toxicity data. 

Anhydrous sodium citrate citric acid monohydrate. 

Each gram of sodium citrate dihydrate represents approximately 10.2 mmol of sodium and 3.4 mmol of citrate. Each gram of anhydrous sodium citrate represents approximately 11.6 mmol of sodium and 3.9 mmol of citrate. 

CAS 68-04-2 (anhyd.) 6132-04-3 (dihydrate) 6858-44-2 (hydrate) EINECS/ELINCS 200-675-3 FEMA 3026 INS331(iii) E331 Synonyms Citric acid trisodium salt Sodium citrate (INCI) Sodium citrate anhydrous Sodium citrate tertiary Trisodium 2-hydroxypropane-1,2,3-tricarboxylate Empirical CeHsNasO (anhyd.) CeHsNasO 2H2O (dihydrate)... 

Citric acid Citric acid monohydrate Ethylenediamine Glycine Hydrochloric acid Magnesium carbonate Magnesium oxide Potassium carbonate Potassium citrate Potassium metaphosphate Potassium phosphate Potassium phosphate dibasic Sodium acetate anhydrous Sodium citrate Sodium hydroxide Sodium lactate Sodium phosphate Sodium phosphate dibasic anhydrous Sodium phosphate dibasic heptahydrate Sodium tri metaphosphate... 

Benedict s solution Is prepared as follows. Dissolve 86-5 g. of crystallised sodium citrate (2Na,C,H(0, l 1H,0) and 50 g. of anhydrous sodium carbonate in about 350 ml. of water. Filter, if necessary. Add a solution of 8-65 g. of crystallised copper Sulphate in 50 ml. of water with constant stirring. Dilute to 500 ml. The resulting solution should be perfectly clear if it is not, pour it through a fluted filter paper. 

Benedict s qualitative reagent (for glucose) dissolve 173 g of sodium citrate and 100 g of anhydrous sodium carbonate in about 600 mL of water, and dilute to 850 mL dissolve 17.3 g of CUSO4 5H2O in 100 mL of water and dilute to 150 mL this solution is added to the citrate-carbonate solution with constant stirring. See also the quantitative reagent below. 

Benedict s quantitative reagent (sugar in urine) This solution contains 18 g copper sulfate, 100 g of anhydrous sodium carbonate, 200 g of potassium citrate, 125 g of potassium thiocyanate, and 0.25 g of potassium ferrocyanide per liter 1 mL of this solution = 0.002 g sugar. 

Citrocarbonate Effervescent Granules—sodium bicarbonate, sodium citrate anhydrous Di-Gel Liquid—aluminum hydroxide, simethicone, saccharin, sorbitol, parabens... 

Two concentrations of citrate have been routinely used as anticoagulant for tests such as PT and APTT (either 0.129 or 0.105 M). The effective molarity depends on whether the dihydrate or the anhydrous citrate salt was used in preparation of the citrate solution. A 3.2% solution of sodium citrate prepared using the dihydrate salt is 0.105 M. However, the molarity of a 3.2% solution of sodium citrate prepared with the anhydrous salt is 0.124 M. Similarly, a 3.8% solution of sodium cit-... 

Oxalate is found to be a frequent impurity in pharmaceutical substances belonging to the category of either organic acids e.g.. anhydrous citric acid, tartaric acid or salts of organic acids e.g., ferrous gluconate, sodium citrate, potassium citrate and sodium cromoglycate. The presence of this impurity is due to the following two prime factors, namely ... 

Procedure Dissolve accurately 22.5 mg of /ram-clomiphene citrate and 52.5 mg of cis-clomiphene citrate (approx. 1 2.3) into 10 ml of DW in a clean 50 ml separating funnel. Add to it 1 ml solution of sodium hydroxide (5% w/v in DW). In the alkaline medium the base is liberated which is extracted successively with 3 portions of solvent ether (10 ml each). The combined ethereal layer is washed with two portions of DW (10 ml each). The resulting ethereal fraction is dried over anhydrous sodium sulphate, filter, evaporate to diyness carefully over an electric water-bath and dissolve the residue in 1 ml of CS2. Now, record the absorption curve in a 0.2 mm cell over the range 12.50 to 14.00 pm. Calculate the absorbance for the peaks at 13.16 and 13.51 pm respectively by employing the base-line method (see section 3. l. B in this chapter) between the minima at 12.66 and 13.89 pm. 

Jin and Zhou have determined 4-aminobenzoic acid in procaine injection solutions by electrophoresis on paper [147]. A 5 pL portion of the injection solution was diluted to 2 mg/mL in procaine hydrochloride, and applied to No. 1 paper (25 cm x 24 cm) for electrophoresis in a JMDY-WI apparatus. The system used a pH 3 buffer solution (9.76 g of citric acid and 1.03 g of sodium citrate in 100 mL), and a potential gradient of 20 V/cm applied for 20 minutes. The paper was then dried and sprayed with a solution containing 100 mL of ethanolic 2% / -dimethylaminobenz-aldehyde and 5 mL of anhydrous acetic acid. A standard solution containing 0.03 pg/pL of 4-aminobenzoic acid was used for comparison. 

While continuing to mix the solution, the para-ben/glycol solution, the remaining propylene glycol, artificial strawberry flavor, artificial banana flavor, saccharin sodium, citric acid anhydrous, and sodium citrate dihydrate are added and mixed until dissolved. 

Diflucan for oral suspension contains 350 or 1400 mg of fluconazole and the following inactive ingredients sucrose, sodium citrate dihydrate, citric acid anhydrous, sodium benzoate, titanium dioxide, colloidal silicon diox-... 

Epivir oral solution is for oral administration. One milliliter (1 mL) of Epivir oral solution contains 10 mg lamivudine (10 mg/mL) in an aqueous solution and the inactive ingredients artificial strawberry and banana flavors, citric acid (anhydrous), methylparaben, propylene glycol, propylparaben, sodium citrate (dihydrate), and sucrose. 

Per 1 mL 2.5 mg albumin (human) 1.2 mg sodium phosphate monobasic monohydrate 1.8 mg sodium phosphate dibasic anhydrate 0.7 mg sodium citrate 5.8 mg sodium chloride 6.8 pg citric acid in WFI, USP... 

The following table provides data on the common salts used for salting out in chromatographic headspace analysis, as applied to direct injection methods and to solid phase microextraction.1 2 Data are provided for the most commonly available salts, although others are possible. Sodium citrate, for example, occurs as the dihydrate and the pentahydrate. The pentahydrate is not as stable as the dihydrate, however, and dries out on exposure to air, forming cakes. Potassium carbonate occurs as the dihydrate, trihydrate, and sesquihydrate however, data are provided only for the anhydrous material. The solubility is provided as the number of grams that can dissolve in 100 ml of water at the indicated temperature. The vapor enhancement cited is the degree of increase of the concentration of vapor over the solution of a 2% (mass/mass) ethanol solution in water at 60°C.3... 

Sodium Citrate occurs as colorless crystals or as a white, crystalline powder. It is anhydrous or contains two molecules of water of crystallization. One gram of the dihydrate dissolves in 1.5 mL of water at 25° and in 0.6 mL of boiling water. It is insoluble in alcohol. 

Sodium acetate, CH3C00Na.3H20 Sodium bismuthate, NaBi03 Sodium carbonate (anhydrous), Na2C03 Sodium chloride, NaCl Sodium citrate, Na3C6H507.2H20... 

Reagent. Dissolve 1.73g of copper sulphate in 10 ml of water. Dissolve 17.3 g of trisodium citrate and 10 g of anhydrous sodium carbonate in 80 ml of water, with the aid of heat pour this solution into the copper sulphate solution and dilute the mixture to 100 ml. 

Anhydrous citric acid fumaric acid malic acid sodium citrate dihydrate tartaric acid. 

Sodium citrate dihydrate consists of odorless, colorless, monoclinic crystals, or a white crystalline powder with a cooling, saline taste. It is slightly deliquescent in moist air, and in warm dry air it is efflorescent. Although most pharmacopeias specify that sodium citrate is the dihydrate, the USP 28 states that sodium citrate may be either the dihydrate or anhydrous material. 

Sodium citrate, as either the dihydrate or anhydrous material, is widely used in pharmaceutical formulations see Table I. 

It is used in food products, primarily to adjust the pH of solutions. It is also used as a sequestering agent. The anhydrous material is used in effervescent tablet formulations. Sodium citrate is additionally used as a blood anticoagulant either alone or in combination with other citrates such as disodium hydrogen citrate. 

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