Anandamide vanilloid receptors

Craib SJ, Ellington HC, Pertwee RG, Ross RA (2001) A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. Br J Pharmacol 134 30-37... [Pg.18]

Al-Hayani A, Wease KN, Ross RA, Pertwee RG, Davies SN (2001) The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. Neuropharmacology 41 1000-1005... [Pg.39]

Ross RA, Gibson TM, Brockie HC, Leslie M, Pashmi G, Craib SJ, Di Marzo V, Pertwee RG (2001) Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. Br J Pharmacol 132 631-640... [Pg.49]

Smart D, Jonsson K-O, Vandevoorde S, Lambert DM, Fowler CJ (2002) Entourage effects of N-acyl ettianolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br J Pharmacol 136 452-458... [Pg.50]

Tognetto M, Amadesi S, Harrison S, Creminon C, Trevisani M, Carreras M, Matera M, Gep-petti P, Bianchi A (2001) Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation. J Neurosci 21 1104-1109... [Pg.50]

Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sdrgdrd M, Di Marzo V, Julius D, Hogestatt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400 452-457... [Pg.51]

Ahluwalia J, Urban L, Bevan S, Nagy I (2003a) Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Eur J Neurosci 17 2611-2618... [Pg.173]

Andersson DA, Adner M, Hogestatt ED, Zygmunt PM (2002) Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists. Mol Pharmacol 62 705-713... [Pg.173]

De Petrocellis L, Bisogno T, Davis JB, Pertwee RG, Di Marzo V (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VRl vanilloid receptor inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett 483 52-56... [Pg.176]

Smart D, Gunthorpe MJ, Jerman JC, Nasir S, Gray J, Muir AI, Chambers JK, Randall AD, Davis JB (2000) The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVRl). Br J Pharmacol 129 227-230... [Pg.183]

Veldhuis WB, van der Stelt M, Wadman MW, van Zadelhoff G, Maccarrone M, Fezza F, Veldink GA, Vliegenthart JF, Bar PR, Nicolay K, Di Marzo V (2003) Neuroprotection by the endogenous cannabinoid anandamide and arvanil against in vivo excitotoxicity in the rat role of vanilloid receptors and lipoxygenases. J Neurosci 23 4127-4133... [Pg.185]

Zygmunt PM, Chuang H, Movahed P, Julius D, Hogestatt ED (2000) The anandamide transport inhibitor AM404 activates vanilloid receptors. Eur J Pharmacol 396 39-42... [Pg.185]

Finally, 2-AG has been found to induce contractions in the longitudinal smooth muscle from the guinea-pig distal colon in vitro in a tetrodotoxin-sensitive manner. This response was mimicked by anandamide, but not by the cannabinoid receptor agonist WIN 55,212-2 or the vanilloid receptor agonist AM404 and was not inhibited by antagonists of cannabinoid or vanilloid receptors (Kojima et al. [Pg.591]

The above observations do not implicate the endothelium in the vasodilator response to anandamide. Other studies, which documented both endothelium-dependent and endothelium-independent components for the vasodilator effect of anandamide, confirmed the role of TRPVl receptors but only for the endothelium-independent component (Jarai et al. 1999 Mukhopadhyay et al. 2002). The endothelium-dependent vasodilator effect of anandamide in the rabbit aorta or the similar effect of abn-cbd in rat mesenteric arteries is unaffected by capsazepine (Mukhopadhyay et al. 2002 Jarai et al. 1999 Offertdler et al. 2003 Ho and Hiley 2003). Interestingly, sensory nerve terminals also appear to have CBi receptors, stimulation of which by very low doses of anandamide or by the synthetic cannabinoid HU-210, neither of which results in activation of TRPVl receptors, inhibits sensory neurotransmission (reviewed in Ralevic et al. 2002). Furthermore, a recent study by Zygmunt et al. (2002) indicates that THC and cannabinol, but not other psychotropic cannabinoids, can elicit CGRP release from periarterial sensory nerves by a mechanism that is independent of not only CBi and CB2 receptors, but also of vanilloid TRPVl receptors. Thus, the sensory nerve-dependent effects of cannabinoids are complex, as interactions with CBi and TRPVl receptors appear to have opposite functional consequences, and there may be additional actions independent of both of these receptors. TRPVl receptors are not involved in the dilation of isolated coronary arteries by anandamide either in the sheep, where the effect is endothelium dependent (Grainger and Boachie-Ansah 2001), or in the rat, where it is endothelium independent (White et al. 2001). Furthermore, in the rat mesenteric arterial bed, the role of sensory nerves and vanilloid receptors in the dilator effect of anandamide was found to be conditional on the presence of NO (Harris et al. 2002). [Pg.614]

Li J, Kaminski NE, Wang DH (2003) Anandamide-induced depressor effect in spontaneously hypertensive rats role of the vanilloid receptor. Hypertension 41 757-762... [Pg.622]

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