Entourage effect

Its hypnotic properties were characterized. Its mechanism of action is far from being understood. Although it does not bind with high affinity to CB] or CB2 receptors, it exhibits some cannabimimetic actions, which could be explained at least in part by entourage effects. It is likely that oleamide and anandamide have common as well as distinct pathways of action. The 5-HT2A receptor appears to be a target for oleamide but the possibility of the existence of specific receptors for this compound is still open. Legget et have reported that oleamide is a full cannabi-... 

T, De PetroceUis L, Di Marzo V, Mechoulam R, An entourage effect Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabi-noid activity, Eur J Pharmacol 353 23—31, 1998. 

Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M. H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V., and Mechoulam, R. (1998). An entourage effect Inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur. 

Smart D, Jonsson K-O, Vandevoorde S, Lambert DM, Fowler CJ (2002) Entourage effects of N-acyl ettianolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br J Pharmacol 136 452-458... 

The formation of both compounds is accompanied by the biosynthesis of cannabinoid-inactive or weakly active congeners, which have been suggested to exert an enhancement of AEA and 2-AG actions via various mechanisms collectively referred to as entourage effects (Ben-Shabat et al. 1998 Mechoulam et al. 1998b for review). 

Production of an "Entourage Effect" by Related Glycerol Derivatives... 

PEA has been demonstrated to potentiate the effects of classical endocannabinoids as anandamide or arachidonoyl glycerol, and this has been called entourage effect [37]. We have recently shown [38] that introduction of a methylene lock on the... 

Russo EB (2011) Taming THC potential catmabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol 163 1344... 

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