Beta-sheet conformation

Alzheimer s Disease. Figure 1 A(3 monomers can self-associate to form dimers, trimers and higher oligomers. Globular structures of synthetic A(342 are known as A(3-derived diffusible ligands (ADDLs) (3-12-mers of A(3). These structures are similar to the smallest protofibrils and represent the earliest macromolecular assembly of synthetic A(3. The characteristic amyloid fiber exhibits a high beta-sheet content and is derived in vitro by a nucleation-dependent self-association and an associated conformational transition from random to beta-sheet conformation of the A(3 molecule. Intermediate protofibrils in turn self-associate to form mature fibers. 

Caughey B, Raymond GJ, Bessen RA. Strain-dependent differences in beta-sheet conformations of abnormal prion protein. J Biol Chem 1998 273 32230-32235. 

Normal prion has alpha helical conformation, the amyloid prion has beta-sheet conformation. 

LeVine, H., 3rd, 4( ) L)ianiIino 1,1 ( )-binaphthyl-5,5( )-disulfonate Report on non-beta-sheet conformers of Alzheimer s peptide beta,, 0. Arch Biochem Biophys, Aug 1,404( 1), 106-115,2002. 

A collection of active protein sequences or protein fragments or subsequences, collected in the form of function-oriented databases, http //bioinformatica. isa.cnr.it/ACS/. AIRS —Autoimmune Related Sequences BAC—Bioactive Peptides CH AMSE—Chameleon Sequences (sequences that can adopt both an alpha helix and beta sheet conformation DORRS — Database of RGD-Related Sequences DVP — Delivery Vector Peptides SSP — Structure-Solved Peptides TRANSIT — Transglutamination Sites. 

Sequences conformation or a beta-sheet conformation. See Minor, D.L., Jr. and Kim,... 

Jahn TR, Radford SE. 2-Microglobulin. In Amyloid Proteins The Beta Sheet Conformation and Disease, Volume 2. Sipe IS, eds. 2005. Wiley-VCH Verlag GmbH Co., Weinheim Germany, pp. 667-696. 

Shibata A, Yamamoto M, Yamashita T, Chiou JS, Kamaya H, Ueda 1 (1992) Biphasic effects of alcohols on the phase transition of poly (L-Lysine) between alpha-helix and beta-sheet conformations. Biochemistry 31 5728-733... 

Kagan BL, Thundimadathil J. Amyloid peptide pores and the beta sheet conformation. Adv Exp Med Biol. 

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