Macromolecular assembly

With/(give numerical value) branch points f-branch 

To describe polymers or polymer blends with greater precision, the qualifiers listed in Table 1.6 have been suggested (Jenkins et al. 1993). In a series of four papers, Wilks (1997a-d) has compared the polymer nomenclature styles and structure representation systems used by Chemical Abstracts Service (CAS), the lUPAC, and MDL Information Systems, Inc. (MDL). 

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Frank J 1996 Three-Dimensional Electron Microscopy of Macromolecular Assemblies (New York Aoademio)... 

Ferre-D Amare, A.R., Burley, S.K. Use of dynamic light scattering to assess crystallizability of macromolecules and macromolecular assemblies. Structure 2 357-359,... 

The preparation of this review was supported in pint by the NSF Center for Polymeric Interfaces and Macromolecular Assemblies (CP1MA) under cooperative agreement DMR-9400354. 

Alzheimer s Disease. Figure 1 A(3 monomers can self-associate to form dimers, trimers and higher oligomers. Globular structures of synthetic A(342 are known as A(3-derived diffusible ligands (ADDLs) (3-12-mers of A(3). These structures are similar to the smallest protofibrils and represent the earliest macromolecular assembly of synthetic A(3. The characteristic amyloid fiber exhibits a high beta-sheet content and is derived in vitro by a nucleation-dependent self-association and an associated conformational transition from random to beta-sheet conformation of the A(3 molecule. Intermediate protofibrils in turn self-associate to form mature fibers. 

Hensley P. Defining the structure and stability of macromolecular assemblies in solution the re-emergence of analytical ultracentrifugation as a practical tool. Structure 1996 4 367-373. 

Benesch, J.L., Robinson, C.V. (2006). Mass spectrometry of macromolecular assemblies preservation and dissociation. Curr. Opin. Struct. Biol. 6, 245-251. 

Amongst the multitude of metals that could be employed as connecting units in dendritic macromolecular assembly, ruthenium is by far the most commonly... 

Con A by the mannoside cluster at concentrations slightly above the nanomolar range, according to a mannose-dependent and partially reversible process. Finally, these results suggested that, rather than an increased avidity for Con A, the unusual potency of these molecular glycoasterisks was due to an efficient and kinetically controlled macromolecular assembly that strongly amplified the effect of these low-valency ligands. 

Urry, D. W. (1998). Five axioms for the functional design of peptide-based polymers as molecular machines and materials Principles for macromolecular assemblies. Peptide Sri. 47, 167-178. 

Tomalia, D. A. and Majoros, I. Chapter 9, Dendrimeric Supramolecular and supra-macromolecular Assemblies in Supramolecular Polymers (A. Ciferri, ed.), Marcel Deker, New York, 359-434 (2000). 

One would assume that the mechanism for delivery of the nucleocapsid through the membrane of the intracellular vacuole has to be provided by the virus. There are no known precedents in normal cell physiology for the passage of macromolecular assemblies like the viral nucleocapsids into the cytoplasm. The most likely mechanism would be fusion of the viral envelope with the vacuolar membrane and subsequent release of the nucleocapsid into the cytoplasm. But if penetration occurs by fusion why would this occur intracellularly and not at the cell surface The clue comes from the low pH dependence of the infection. 

Table 3. lUPAC Source-Based Nomenclature for Non-Linear Macromolecules and Macromolecular Assemblies [5]... 

Macromolecule or macromolecular assembly Qualifier Example Commeut... 

The following procedure is employed to name both non-linear macromolecules and macromolecular assemblies ... 

The following italicized qualifiers can be used as both prefixes (e.g. blend-, net-) and connectives (e.g. -blend-, -net-), separated by (a) hyphen(s) from the constituent name(s), to designate the skeletal structure of non-linear macromolecules or macromolecular assemblies ... 

Source-based nomenclature for non-linear macromolecules and macromolecular assemblies (lUPAC Recommendations 1997), PureAppl. Chem. 69, 2511-2521 (1997). Reprinted as Chapter 20, this edition. 

The authors thank Miss Jenny Kolsenik for her skillful artwork. Financial support from the G. M. J. Schmidt Minnerva Center on supermolecular architecture, the Israel Science Foundation, the Helen and Martin Kimmel center for molecular design and the Kimmel-man Center for Macromolecular Assemblies are greatly acknowledged. A. S. Holds the Siegfried and Irma Oilman Professorial Chair. 

Tomlinson MR, Genzer J (2003) Eormation of grafted macromolecular assemblies with a gradual variation of molecular weight on soUd substrates. Macromolecules 36 3449-3451... 

It is worth to mention that this definition is not always consistent with the nature of the macromolecular assembly when applying to nucleic acids. For example, from all different types of quadruplex nucleic acids only quadruplex monomers are covered by lUPAC definition of tertiary structure being a single chain of DNA or RNA. However, also the quadruplexes with higher molecularity of the formed structures (dimers, tetramers) belong to this important tertiary structure family. 

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