Amyloid beta Aggregation

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I. Choi, Y. Huh, D. Erickson, Ultra-sensitive, label-fiee nobing of the conformational characteristics of amyloid beta aggregates with a SERS active nanofluidic device. Microfluid. Nanofluid. 12, 663 (2012)... 

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Tomiyama, T., Asano, S., Suwa, Y., Morita, T., Kataoka, K., Mori, H., andEndo, N. (1994). Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro. Biochem. Biophys. Res. Commun. 204, 76-83. 

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Perutz, M. F., Pope, B. J., Owen, D., Wanker, E. E., and Scherzinger, E. (2002b). Aggregation of proteins with expanded glutamine and alanine repeats of the glutamine-rich and asparagine-rich domains of Sup35 and of the amyloid beta-peptide of amyloid plaques. Proc. Natl. Acad. Sci. USA 99, 5596-5600. 

Paresce DM, Ghosh RN, Maxfield FR. 1996. Microglial cells internalize aggregates of the Alzheimer s disease amyloid beta-protein via a scavenger receptor. Neuron 17(3) 553-565. 

Ramsden, M., Plant, L. D., Webster, N. J., Vaughan, P. F., Henderson, Z., and Pearson, H. A. (2001). Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones. J Neurochem 79, 699-712. 

Ye, C., Walsh, D. M., Selkoe, D. J., and Hartley, D. M. (2004). Amyloid beta-protein induced electro-physiological changes are dependent on aggregation state N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neurosci Lett 366, 320-325. 

Cumming, R. C., Schubert, D. Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer s disease. FASEB J. 2005,19 2060-2062. 

Kawahara M, Muramoto K, Kobayashi K, Mori H, Kuroda Y (1994) Aluminum promotes the aggregation of Alzheimer s amyloid beta-protein in vitro. Biochem Biophys Res Commun 198 531-535... 

Riesner, D. (1998). Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer s patients by fluorescence correlation spectroscopy. Nat. Med. 4, 832-834. 

Luchsinger JA, Reitz C, Honig LS, Tang MX, Shea S, Mayeux R (2005) Aggregation of vascular risk factors and risk of incident Alzheimer disease. Neurology 65 545-551 Mark RJ, Lovell MA, Markesbery WR, Uchida K, Mattson MP (1997) A role for 4-hydroxynonenal, an aldehydic product of hpid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem 68 255-264 Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer s disease. Free Radic Biol Med 23 134-147... 

Zinc and Amyloid Beta (AfS) Peptide Processing and Aggregation. 680... 

Klunk WE, Jacob RF, Mason RP. Quantifying amyloid beta-Peptide (Abeta) aggregation using the congo red-abeta (CR-Abeta) spectrophotometric assay. Anal. Biochem. 1999 266 66. 

AP Amyloid-beta is a peptide of 39 3 amino acids that is the main constituent of amyloid plaques in the brains of Alzheimer s disease patients. Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis, a muscle disease. Ap also forms aggregates coating cerebral blood vessels in cerebral amyloid angiopathy. 

Sharoar MG, Thapa A, Shahnawaz M, Ramasamy VS, Woo ER, Shin SY et al (2012) Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. J Biomed Sci 19 104... 

Alzheimer s disease (AD) is the most common form of age-related dementia. The disease manifests in the form of progressive cognitive decline with early memory loss and subsequent deficits in intellectual fimctions [1]. The neuropathology of the disease is characterized by extracellular deposition of aggregated amyloid beta (Ab) protein and intraneuronal formation of neurofibrillary tangles [2,3]. 

Louzada PR Jr, Paula Lima AC, de Mello FG et al (2001) Dual role of glutamatergic neurotransmission on amyloid beta(l-42) aggregation and neurotoxicity in embryonic avian retina. Neurosci Lett 301 59-63... 

Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of amyloid-beta protein causes peptide aggregation and neurotoxicity. Brain Res 573 311-314... 

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