AMP signaling

G-protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders effects of diagnosis, suicide, and treatment at the time of death. J. Neurochem. 73, 1121-26. 

J. L. Martiel and A. Goldbeter, A model based on receptor desensitization for cychc AMP signaling in Dictyostelium cells. Biophys. J. 52, 807-828 (1987). 

A. Goldbeter and L. A. Segel, Control of developmental transitions in the cyclic AMP signaling system of Dictyostelium discoideum. Differentiation 17, 127-135 (1980). 

Mork, A. (1993) Actions of lithium on the cyclic AMP signalling system in various regions of the brain—possible relations to its psychotropic actions. A study on the adenylate cyclase in rat cerebral cortex, corpus striatum and hippocampus. Pharmacol Toxicol 73 1 7. 

Conti, M., Richter, W., Mehats, C., Livera, G., Park, J. Y. (2003) Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J Biol Chem 278,5493. 

Incorporation of phosphatidyl choline and AMP signals into the large, broad envelope was unexpected because it had not been observed before with studies involving model compounds in a concentrated humic matrix with FeEDTA present (44). However, these model compound studies were conducted at a phosphorus concentration of 150 mg of P/L, a concentration 10 times greater than the amount that was spiked into sample I. This fact,... 

Butler JJ, Mader JS, Watson CL, Zhang H, Blay J, Hoskin DW (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules role of interleu-kin-2 and cyclic AMP signaling pathways. J Cell Biochem 89(5) 975—991... 

He Y, Grinnell F. Stress relaxation of fibroblasts activates a cyclic AMP signaling pathway. J Cell Biol. 1994 126 457-464. 

Marcil, J., Schiffiui, E. L. and Anand-Srivastava, M. B. Aberrant adenylyl cyclase/cyclic AMP signal... 

Figure 15. Schematic of nitric oxide mediated signaling. Protein kinase G (PKG) responds to c-GMP, much as PKA responds to c-AMP. An interaction between c-GMP and c-AMP signaling also occurs. See text for a more detailed explanation.

How do hormones trigger the breakdown of glycogen They initiate a cyclic AMP signal-transduction cascade, already discussed in Section 16.1 (Figure 21.15). 

Herring AC, Koh WS, Kaminski NE (1998) Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem Pharmacol 55 1013-1023... 

Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (1994) Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction. J. Biol. Chem., 269, 1231-12. 

G protein from the receptor. The fi-arrestim recruit proteins such as PDE4 (which limits cyclic AMP signaling), and others such as clathrin and fi -adaptin, promoting sequestration of receptor from the membrane (internalization) and providing a sccffold that permits additional signaling steps. 

Abdel-Latif AA (1991) Biochemical and functional interactions between the inositol inositol l,4,5-trisphosphate-Ca and cyclic Amp signalling systems in smooth muscle. Cell Signal 3 371-385... 

Goldbeter, A. 1981. Bifurcations and the control of developmental transitions Evolution of the cyclic AMP signalling system in Dictyostelium discoideum. In Mathematical Biology. Towards a Molecular Science. T. Burton, ed. Pergamon Press, New York, pp. 79-95. 

Goldbeter, A. J.L. Martiel. 1985. Birh5dhmicity in a model for the cyclic AMP signaling system of the slime mold Dictyostelium discoideum. FEBS Lett. 191 149-53. 

Martiel, J.L. A. Goldbeter. 1985. Autonomous chaotic behaviour of the slime mould Dictyostelium discoideum predicted by a model for cyclic AMP signalling. Nature 313 590-2. 

Robertson, A. D.J. Drage. 1975. Stimulation of late interphase Dictyostelium discoideum amoebae with an external cyclic AMP signal. Biophys. J. 15 767-75. 

Roos, W., V. Nanjundiah, D. Malchow G. Gerisch. 1975. Amplification of cyclic-AMP signals in aggregating cells of Dictyostelium discoideum. FEBS Lett. 53 139-42. 

As expected, earlier studies focused on mechanisms that involve eicosanoid metabolites. More recently, however, the effects of fatty acids on gene expression have been investigated and this focus of interest has led to studies at the molecular level (Tables 8, 9). Previous studies have shown that fatty acids, whether released from membrane phospholipids by cellular phospholipases or made available to the cell from the diet or other aspects of the extracellular environment, are important cell signaling molecules. They can act as second messengers or substitute for the classic second messengers of the inositide phospholipid and cyclic AMP signal transduction pathways. They can also act as modulator molecules mediating responses of the cell to... 

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