Amino propionates

Electrochemical fluorination of cyclic 2-(dialkylamino)-propionic acids provides a general route to optically active perfluoro-(2-cycIic(dialkyl-amino)-propionic acids [91 JFC(52) 133], which are a source of perfluorinated vinylamines (88CL1887). 

Casanola-Martin GM et al. (2006) New tyrosinase inhibitors selected by atomic linear indices-based classification models. Bioorg Med Chem Lett 16(2) 324-330 Tan CY, Wainman D, Weaver DF (2003) N-, alpha-, and beta-substituted 3-amino-propionic acids design, syntheses and antiseizure activities. Bioorg Med Chem 11(1) 113-121... 

US patent 6,767,921, Polymorphic forms of fasidotril, their methods of preparation and pharmaceutical compositions comprising them [115]. The subject of this invention are polymorphic Forms I, II, III, IV of benzyl (S,S)-2-(2-acetylsul-phanylmethyl-3-benzo[l,3]dioxol-5-ylpropionyl-amino)propionate (i.e., fasidotril), their methods of preparation, and novel pharmaceutical compositions containing them. 

VDC polymer degradation and, 25 717 2-Alkyl-alcohols. See Guerbet alcohols Alkylalkanolamines, 2 140 Alkylaluminum compounds, 2 285 Alkylaluminum halides, 2 358 Alkylaluminum reagents, in triorganotin preparation, 24 815-816 Alkyl amino acids, protonated, 17 780 Alkylaminomethanols, 12 112 AT-Alkyl amino propionates, 24 148... 

Nonoligomeric libraries. Peptide and peptoid libraries are examples of oligomeric (polymeric) libraries made up of repeating monomers (a-amino acids, A-substitutcd glycines). Random libraries composed of nonoligomeric compounds have been extensively explored. One illustration comes from the former laboratories at Organon (Fig. 1.6) (16). Thirteen different secondary amino-phenol inputs were attached to solid support by reaction with REM resin yielding resin-bound b-amino propionates. Two-site derivatization was then used to drive library diversity. The free phenolic OH was subjected to O-alkylation,... 

Whereas cyclization of 2-(3-chloropropionamido)quinolines (210) afforded 2,3-dihydro-l//-pyrimido[l,2-a]quinolin-3-ones (211), an attempted thermal cyclization of ethyl 3-[(2-quinolyl)amino]propionate (212) gave only 2-amino-6-chloro-4-phenylquinoline-3-nitrile (73YGK313). 

Reaction of (A-benzyl-amino) propionic acid 337a and its 3-methyl derivative 337b with phenylphosphonic dichloride in the presence of excess of NEt3 gave the diazocinediones 9a,b, which have a cyclo-/3-dipeptide structure (Equation 13). The reaction was performed under different reaction conditions, that is, changing solvents, temperature, reaction time, and reactant concentration. The best results (54-68% yields) were obtained in benzene at 80°C for 20h. The diazocinediones 9a,b were formed in similar yields at high and low concentrations of the reactant <2001T1883>. 

Solid-phase synthesis has also been used to make peptoids, some examples of which are shown in Fig. 2.4. Compounds of general structure 2.8, where the amino acid side chain is on the nitrogen, have been prepared either by the corresponding Fmoc-protected N-aUcylated glycines (33) or, in an improved method, via treatment of a resin-bound secondary amine with bromoacetic acid to produce the first peptoid building block, which is then elaborated via iteration of the procedure (34). Other modified P-peptoid structures such as 2.9 with repeating P-amino propionic units have been prepared by acylation of a resin-bound amine with acriloyl chloride followed by Michael addition of a primary amine. The cycle is repeated to build up the polymer... 

The addition of ammonia to acrylonitrile gives /S-aminopropionitrile and fczs-(/S-cyanoethyl)-amine. The former is hydrolyzed directly to /S-amino-propionic acid (90%) by barium hydroxide, " and the latter may also be converted through the intermediate phthalimide to the same amino acid (6S)%). A variation of this procedure involves condensation of phthalimide and acrylonitrile to /S-phthalimidopropionitrile, Both amino and carboxyl groups are formed during the subsequent hydrolysis by hydrochloric acid. The free /S-alanine (75%) is liberated from the hydrochloride by lithium hydroxide. ... 

By this synthesis, it will be noticed that the alpha- immo acids result as the amino group is always linked to the carbon to which the carboxyl is also linked. The amino acid will also contain one more carbon than the aldehyde or ketone due to the addition of the cyanide radical, i.e.y acetic aldehyde yields amino propionic acid and propanone (acetone) yields amino iso-butyric acid. 

Di-amino Acetic Acid, CH(NH2)2—COOH This acid has also been obtained as a hydrolytic product of proteins. Alanine, CH3—CH(NH2)—COOH, a-Amino Propionic Acid... 

Tryptophane Skatole amino acetic acid -Indole a-amino propionic acid ... 

Chloromercuriphenyl-a-amino) propionic ethyl ester, 127. 2-Chloromercuriphenylglyoine ethyl ester, bromide, iodide, 127. 5-Chloromerouri-2-phenyl thiophene, 99. 

When heated in dimethylformamide, the tetrahydropyrrolo[l,2-a]quina-zolin-3-one 477 isomerized to the dihydropyrrolo[l,2-a]quinazolin-3-ol 479. The pyrimido[ 1,2-fl]quinazolinedione 483 resulted from the reaction of 3-[(0-carbamoylphenyl)amino]propionic acid (484) with ethyl chloro-... 

Protonated methyl 1-amino-propionate AlaCi C4H10NO2 104.13... 

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