2- amino-1 -phenyl-1 -propyl propionate

C. 2-(N-Benzyl-N-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate, 1. To a solution of 3 (15.0 g, 35.4 mmol) and pyridine (3.7 mL, 46 mmol) in dichloromethane (200 mL), propionyl chloride (3.8 mL, 44 mmol) (Note 1) is added dropwise at 0°C. The reaction mixture is stirred at room temperature for 13 hr and diluted with diethyl ether (300 mL). The mixture is washed successively with 100 mL each of water, 1 M HCI, water, saturated sodium hydrogen carbonate solution, and brine, and dried with anhydrous sodium sulfate. The filtered organic solution is concentrated to give a crystalline residue, which is triturated with hexane to give 1 (16.8 g, >99%) (Note 7). 

N-Benzyl-N-mesitylenesulfonyl)amino-1 -phenyl-1 -propyl propionate Benzenesulfonamide, 2,4,6-trimethyl-N-[1 -melhyl-2-(1 -oxopropoxy)-2-phenylethyl]-N-(phenylmethyl)-, [R-(R, S )]- (14) (187324-66-9)... 

N-BENZYL-N-MESITYLENESULFONYL)AMINO-1-PHENYL-1-PROPYL PROPIONATE 109... 

N-Benzyl-N-mesitylenesulfonyl)amino-1 -phenyl-1 -propyl Propionate. A. Abiko, Venture Laboratory, Kyoto Institute of Technology,... 

Stability of 4-membered heterocyclics. A soln. of a-phenyl-a-n-propyl-)( -amino-propionic acid in 25%-acetic acid added at 0-5° during 0.5 hr. to aq. NaNOg, stirring continued 1.5 hrs. at 0° a-phenyl-a-n-propyl-y -propiolactone. Y 78%.—4-membered heterocyclics are stabilized by disubstitution in position 3. F. e. s. E. Testa et al., A. 619, 47 (1958) cf. Synth. Meth. 15, 206. 

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