2-Methyl-l,2-propanediol

Methyl-l,2-propanediol Acetal CHCI3 Amb. Benzoyl chloride6 55 7 84... 

Amino-2-methyl-l,3-propanediol [115-69-5] M 105.1, m 111 , b 151-152 /10mm, pK 8.80. Crystd three times from MeOH, dried in a stream of dry N2 at room temp, then in a vacuum oven at 55 . Stored over CaCl2 [Hetzer and Bates J Phys Chem 66 308 1962],... 

Elution 0.05 M GTA buffer, pH 7.0 (G, 3,3-dimethylglutaric acid T, trishydroxyaminomethane A, 2-amino-2-methyl-l,3-propanediol) plus indicated salt. 

Methylnitropropanediol (2-Nitro-2-methyl-l, 3-propanediol). Clfe. C(N02)(CH20H)2 mw 135.12, N 10.37% monocl crysts mp 149— 51° bp decompn. Sol in w (80p in lOOp at 20°) and in ale. Can be prepd by treating a mixt of nitroethane and formaldehyde in w with a small amt of K bicarbonate as catalyst. On nitration, it yields an expl, 2-Methyl-2-nitro-1,3-propanediol dinitrate (see below)... 

Hydroxy-methyl-2-methyl-l-2-methyl-1,3- propanediol. See Trimethylolethane... 

Reaction of dihalo- and trihaloacetic acid and a,a-dihalopropionic acid with trimethylolethane (2-hydroxymethyl-2-methyl-l,3-propanediol) to give bicyclic ortho esters [204]. 

Hydroxymethyl-2-methyl-l,3-propanediol see l,l,l-tris(hydroxymethyl)ethane. 

Amino-2-methyl-l,3-propanediol Dinitrate under Aminomethylpropanediols in Vol l,p A232 -R... 

Two isomers are described in the literature 2-Methyl-l,2,3-propanetriol or f3-Methylgylcerol, CH2(OH).C(CH3XOH).CH2.OH, col vis liq, bp 115-20° at 1.6mm. d 1.186 at 20°, nD 1.4730 at 20°, can best be prepd by hydration of /S-methyl-glycidol(2,3-epoxy- 2-metiiyl-l-propanol), and can be prepd directly from either dichloro-tert-butyl alcohol or /3-methylglycerol monochlorohydrin(Ref 2). See also Refs 1,4 5) and 2-(Hydroxymetby[)-l,3-propanediol or Trimethylol Methane, CH2(OH).CH(CH2OH)2 was prepd by Fujii(Ref 3) from a mixt of acetaldehyde formaldehyde(10 25 mol) heated with Ca(OH)2 and the product reduced with H in the presence of Ni... 

Amino-2-methyl- l, 3 propanediol 2-Amino-2-methyl-1,3-dibydroxy-propane or Bis(by-droxymethyl)metbyl-aminometbawe(called in Beil /3-Amino-/S-methyl-trimethylenglykol), HO-CHj-CfNHj )-CHa -OH... 

Note R.C.Elderfield et al [OSRD Rept 158 (1941), 7-8] prepd by condensing 2-amino-2-methyl-l,3-propanediol with 2,4-dinitro-chlorobenzene the product identified as 2,4-dinitrophenyl-bisfhydroxymethyl)-methylamine, mp 162—3°, which on nitration with mixed nitricsulfuric acid gave 2,4,6- trini trophenyl-( bi s- hydroxy )-tert-butylnitramine dinitrate, mp 159°,(See also under Anilinomethylpropanediol... 

Metriol (Pentaglycerol, 2-(Hydroxymethyl)-2-methyl-l, 3-propanediol, Methyltrimethylol-methane). H3G.C(CH20H)3 mw 120.15 white needles from abs ale mp 199° (sublimes without decompn). Was first prepd by Hosaeus (Ref 2) by condensing formaldehyde and propionic aldehyde in cold aq soln in the presence of lime. Metriol is v sol in w, ale and acet ac is insol in eth. It may be nitrated to an expl trinitrate, and acetylated to a nonexpl triacetate Refs 1) Beil 1, 520 2) H. Hosaeus, Ann... 

Fig. 15.1 Synthesis generating dansyl-boronic receptors for fructose and building blocks, (i) DMS/Cs2C03 NH4Cl/dioxane, (ii) CH3I/K2C03, (iii) PC13/THF, (iv) 2-methyl-l,3-propanediol-3-amine-phenyl boronate...

Similar to basic drugs, development of pH-independent ER matrices for weakly acidic drugs is possible with incorporation of non-polymeric bases/salts of strong bases and polymeric pH modifiers [67-70]. The examples of basic excipients are sodium, potassium or magnesium salts of (bicarbonate, phosphate or hydroxide, magnesium oxide, 2-amino-2-methyl-l,3-propanediol (AMPD) and Eudragit ElOO. 

Page 24, 2-Amino-2-methyl-l,3-propanediol, following tine,read [1, 37, before 2-Amino-2-methyl-l-propanol). Mol. 

TBA concentrations in blood at the end of the exposure period were 5.7 0.8 xM and 21.7 4.9 xM, respectively. TBA was also present in the blood of non-exposed rats at a concentration of l.l 0.7 xM. The total urinary metabolites corrected for background occurrence constituted 50% (1.1 0.7 xM) and 53% (10.9 3.1 xM) of the received low and high doses, respectively. All ETBE metabolites measured (TBA, 2-methyl-1,2-propanediol and 2-hydroxybutyrate) were quantifiable even in unexposed rats (Table 3). The major urinary metabolite at both exposure levels was 2-hydroxyisobu-tyrate. In contrast, the quantity of TBA hardly differed from background and 2-methyl-1,2-propanediol was excreted in small quantities in urine. 

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