Amine derivatives structures

The half-lives shown in the table ". ill vary depending on the structure of the Fmoc-amine derivative. 

The Fmoc group is cleaved under mild conditions with an amine base to afford the free amine and dibenzofulvene. The accompanying table gives the approximate half-lives for the deprotection of Fmoc-ValOH by a variety of amine bases in DMF. ° The half-lives shown in the table will vary, depending on the structure of the Fmoc-amine derivative. 

Imidodisulfates can also be obtained by hydrolysis of nitridotrisulfates (see below). Figure 15.51 compares the structure of the imidodisulfate and parent disulfate ions, as determined from the potassium salts. Comparison with the hydroxyl-amine derivative K[HN(0H)S03] (below) is also instructive. 

Dobanol Ethoxy late [443], At least 16 Triton units with mass 910 were observed. A study of the reactions of amines and amine derivatives with scC02 using cSFC-MS was also reported [448], Both cSFC-APCI-MS and cSFC-ESI-MS of PEG 600 and PPG 425 were described [416]. Direct insertion probe (DIP) methodology was used for the structure analysis of the antistatic agent V,fV-bis-(2-hydroxyethyl)alkylamine. When analysed by SFC-MS coupling, the same sample could be separated into six components. The alkyl chains consist of saturated Cn, Ci4, C16 and C18 chains and of Cig chains with one double bond where 18 1 and 16 0 chains dominate. 

Based on the foregoing discussion, it is possible to formulate some structure-activity relationships with respect to the behavioral properties of various trypt-amine derivatives. It should be noted that these structure-activity relationships are derived from the results of both human and animal studies. 

As shown by mass spectrometry and NMR spectroscopy, these amine derivatives of Cgfl, after work up, are dehydrogenated adducts [81]. After nucleophilic addition, the H atoms brought in by the diamines were oxidatively eliminated. The final adduct formation of the secondary diamines proceeds exclusively at [6,6] bonds. Besides the monoadduct, most of the regioisomeric bisadducts of piperazine or N,N -dimefhylethylenediamine and Cjq could be separated by column chromatography. The structure of the monoadduct and some of these bis-adducts were proven by X-ray crystal-structure analysis [90]. 

An example of the exo-exo configuration is seen with the bis(borane-amine) derivative of [2.2.2]cryptand (Figure 7c) in which both of the large borohydride groups point away from the cavity. In contrast, the mono(borane-amine) derivative of [l.l.l]cryptand takes up an endo-exo structure in the crystal (78NJC615). 

The reaction of carbonyl sulfide with [M(02)(PPh3)2] (where M = Pd or Pt) has resulted in the first reported examples of transition metal complexes of the monothiocarbonate anion (47 R = O-). Bidentate S—O coordination was concluded from 3IP H NMR analyses of these compounds.184 A short structural review of metal complexes of monothiocarbamate ions (47 R = N(R )R") demonstrates their varied coordination chemistry.185 In complexes of the dialkyl forms the sulfur atom is seen to have considerable mercaptide character , whereas aromatic amine derivatives demonstrate C—S and M—S partial multiple bonding.185,251 A review on the coordination chemistry of these ligands has appeared.186 Additional detail is provided in Chapter 16.4 of this volume. 

B is correct Of course you don t need to know the structure of benzamide. But you should know that it s an amide derivative of benzene. B is the only amine with benzene. Also, you will see in Organic Chemistry Lecture 2 that benzene undergoes substitution, so answers C and D imply that a nitrogen has replaced a carbon atom in the benzene ring these structures cannot be correct. Answer choice A is the amine derivative of benzene, aniline, not the amide derivative. And finally, D requires a positive charge on the nitrogen atom. 

In addition to forming known types of molecules in only a few steps, this process also enables the synthesis of a variety of novel structures and heterocycles with a high degree of molecular diversity. The commercial availability of an increasing number of structurally novel boronic acids and amine derivatives facilitates their further incorporation into the many types of products that can be synthesized. 

Amongst amine derivatives containing tellurium atoms, where Te can perform as the donor atom, there are a number of compounds with complex-forming characteristics. The following structures exemplify several complex compounds synthesized in this manner 511 [903,904], 512 [13,633,634a,903,905,906], 513 [636a,907], and 514 [903,908] ... 

This class of ligands mostly consists of derivatives of pyridine, 2.2 -bipyridinc. 2,2, 2"-ter-pyridine, and 1,10-phenanthroline. Scheme 6 shows the structures of fourEu3+ chelates with aromatic amine derived ligands, that can be covalently bound to proteins, for time-resolved fluorometry, among which 4,7-bis(chlorosulfophenyl)-l,10-phenanthroline-2,9-dicarboxylic acid (BCPDA)-Eu3+ and trisbipyridine cryptate (TBP)-Eu3+ are widely used for europium fluorescence labels in TR-FIA. 

It has been reported that the effectiveness of copolymerized DOPO-type monomers can be further improved if the alcohol-amine derivatives of DOPO, for example, Structure 5.11, are used rather than similar structures not containing nitrogen.30 Of the FR fibers based on P-containing comonomers, it has been found that those based on Structure 5.10 are more hydrolytically stable, presumably because the P-containing group is in a cyclic structure and also should the hydrolysis of the P-0 bond occur, it will not lead automatically to a marked reduction in molecular weight.31 All the P-modified PETs appear to be subject to both the vapor-and condensed-phase mechanisms of flame retardance, with the former predominating.32 33... 

Platinum (IV) Structures. The oxidation state of the platinum atom in platinum coordination compounds determines the steric configuration of the molecule platinum(II) structures are planar molecules, while platinum(IV) derivatives assume an octahedral shape. Though it was hoped that these differences could be used to circumvent platinum resistance, the two compounds developed in the clinic, iproplatin and ormaplatin, have not proven useful. In the case of the former, testing in Phase-II trials failed to reveal activity. In the case of ormaplatin, the platinum(IV) configuration is not maintained under biological conditions conversion to a platinum(II) metabolite occurs within minutes [14], A series of novel platinum(IV) and mixed ammine/amine derivatives being developed at the Institute for Cancer Research are described in this volume by Kelland. 

The nitrile is then hydrogenated to a primary amine from which amine derivatives can be made by utilization of a variety of reagents [6, 7]. The example in eqns 6.1.1-6.1.3 shows the conversion of fatty acid to dialkyl secondary amine via catalytic deammoniafication (for this and all subsequent structures n = 80-20 unless otherwise noted) ... 

The previous parts of Sect. 5 testify to the fact that development of sensors for a given chemical species is dependent on the availability of receptors with suitable selectivity, electroactivity and optical transparency. These criteria were most easily satisfied with amine derivatives with various structural modifications for the binding of protons, alkali and alkaline earth cations. Such is the ubiquity of the amine motif in fluorescent PET research that several of the examples to be discussed in this section also contain it within their receptors. 

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