Amination nitric oxide

Title Hindered Amine Nitric-Oxide-Donating Polymers for Coating Medical Devices... 

Saavedra, J.E., Dunams, T.M., Flippen-Anderson, Ji., and Keefer, L.K. (1992). Secondary amine/nitric oxide complex ions, R2n[N(0)No]-0-functionalization chemistry. J. Oig. Chem. 57, 6134-6138. 

Monoammonium phosphate Diammonium phosphate Nitric oxide Actylonitrile Caprolactam Monomethylamine Dimetliylamine Hexametliylenetetramine Trimetliylamine Monoethanolamine Dietlianolamine Trietlianolamine Hydrogen Cyanide Fatty nitrogen compounds (nitriles, amines, quaternary ammonimn compounds)... 

This statement does not mean, however, that the mechanism of diazotization was completely elucidated with that breakthrough. More recently it was possible to test the hypothesis that, in the reaction between the nitrosyl ion and an aromatic amine, a radical cation and the nitric oxide radical (NO ) are first formed by a one-electron transfer from the amine to NO+. Stability considerations imply that such a primary step is feasible, because NO is a stable radical and an aromatic amine will form a radical cation relatively easily, especially if electron-donating substituents are present. As discussed briefly in Section 2.6, Morkovnik et al. (1988) found that the radical cations of 4-dimethylamino- and 4-7V-morpholinoaniline form the corresponding diazonium ions with the nitric oxide radical (Scheme 2-39). 

Morkovnik et al. (1989) found experimentally that the addition of an equimolar amount of 4-morpholino- or 4-dimethylaminoaniline to a suspension of nitrosyl perchlorate in 100 % acetic acid, dioxan, or acetonitrile yields a mixture of the diazonium perchlorate and the perchlorate salt of the amine radical cation, with liberation of gaseous nitric oxide. Analogous results in benzene, including evidence for radicals by ESR spectroscopy and by spin trapping experiments, were obtained by Reszka et al. (1990). 

Amin-Hanjani S, StagUano NE, Yamada M, Huang PL, Liao JK, Moskowitz MA. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endotheUal nitric oxide synthase in mice. Stroke 2001 32 980-986. 

Indeed, given an improperly designed or understood system, a blocking agent, like ascorbic acid, could be catalytic toward nitrosamine formation. For example, if the source of nitrosatlng agent is nitrite ion and the susceptible amine is in the lipid phase, conceivably ascorbic acid could cause the rapid reduction of nitrite ion to nitric oxide which could migrate to the lipid phase. Subsequent oxidation of NO to NO in the lipid phase could cause nitrosation. 

These are the most common diazeniumdiolates, formed by the reaction of secondary amines and polyamines with nitric oxide in basic media [214, 215]. They are stable solids, capable of regenerating two equivalents of nitric oxide along with the starting amine in neutral or acidic buffers. The half-life of NO generation varies from a few seconds to many hours, depending on the amine. The decomposition to NO is a spontaneous, first-order reaction at constant pH. 

In this reaction phenylhydroxylamine behaves like a secondary amine. To the class of nitrosohydroxylamines there belong also the so-called isonitramines and the compound of nitric oxide and potassium sulphite. 

Tin, in the presence of hydrochloric acid, reduces nitric oxide to hydroxyl-amine. The overall molecular equation may be as follows ... 

Hantzsch synthesis The reaction of 1,3-dicarbonyl compounds with aldehydes and NH3 provides a 1,4-dihydropyridine, which can be aromatized by oxidation with nitric acid or nitric oxide. Instead of NH3, primary amine can be used to give 1-substituted 1,4-dihydropyridines. 

Several patents exist on the use of mixtures of nitrogen dioxide (N02) and nitric oxide (NO) as the reactant for the preparation of Y-nitroso compounds of secondary amines, both in the liquid and in the vapor state, usually in a flow reactor [31,32]. These reactions are not limited to dialkyl amines, as the earlier... 

Marqueyrol [74] reported experiments carried out in France over a period of 15 years to compare the efficiency of various stabilizers. The results are shown in Table 175. In addition to amyl alcohol and diphenylamine, the action of N-nitrosodiphenyl-amine (diphenylnitrosamine), carbazole, diphenylbenzamide, nitronaphthalene and naphthalene was also tested. The powder was stored at temperatures of 40, 60 or 75°C. The experiments were stopped when the powder showed signs of intense decomposition, giving off nitric oxides. This was also manifested by a sudden fall pf the nitrogen content in nitrocellulose isolated from the samples. 

Mammals have several classes of hormones, distinguishable by their chemical structures and their modes of action (Table 23-1). Peptide, amine, and eicosanoid hormones act from outside the target cell via surface receptors. Steroid, vitamin D, retinoid, and thyroid hormones enter the cell and act through nuclear receptors. Nitric oxide also enters the cell, but activates a cytosolic enzyme, guanylyl cyclase (see Fig. 12-10). 

The divalent catalyst is highly coordinatively unsaturated and therefore exhibits some unusual chemistry (33-42). It has a light green color but quickly truns blue when exposed to N2, indicating a weak chemisorption. Carbon monoxide is adsorbed to yield a violet color, and of course it poisons the polymerization. Up to two molecules can be adsorbed. Olefins also adsorb in a 2 1 ratio, and acetylene is converted to benzene. Polar compounds like alcohols, ethers, or amines are strongly held. Nitric oxide (NO) attaches in a 2 1 ratio. 

Nitric oxide, a gas, is an improbable compound for a neurotransmitter. It is not an amine, amino acid, or peptide it is not stored in synaptic vesicles or released by... 

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