Sulfur compounds amides

An interesting bridged-sulfur compound, which is a natural constituent of Iranian oil, has been synthesized 478) by the reaction of a bicyclic bis-enamine with sulfur dichloride and subsequent Wolff-Kishner reduction of an initial sulfur-bridged diketone. Sulfur dichloride has also been added to a number of vinylogous amides 479). 

Rhenium(VI) complexes, 4,194 alkoxides, 4,196 amides, 4,194 amines, 4,199 carboxylates, 4,199 dimethylformamide, 4,199 dioxane, 4,198 halides, 4,195,199 2-hydroxypyridine, 4,199 imides, 4,194 magnetic behavior, 1,271 mixed sulfur-nitrogen compounds, 4,196 N heterocycles, 4,199 nitrides, 4,194 oxide halides, 4, 195 oxoanions,4,196 pyridine, 4,199 sulfates, 4,198 sulfur compounds, 4,196 tellurates, 4,198... 

The steric bulk of the thioamide sulfur results in conformational changes that have been documented in cyclopentapeptide and cyclohexapeptide model systems (for more details see Vol. E22b, Section 6.8.5.2.1). For example, in c[-Proi(>[C(=S)-NH]Gly-Pro-Gly-D-Phe-], the first synthetic cyclic thiopeptide, an intramolecular y-turn seen in the all-amide parent compound by NMR methods was perturbed by the putative interaction of sulfur with the adjacent Pro s (3-protons.[9 On the other hand, in a cyclic hexapeptide, the enhanced H-bond donor capacity of the thioamide NH led to the formation of a relatively strong intramolecular H-bond stabilized (3-turn, which was frame shifted compared to that found in its all-amide parent peptide. 10 ... 

Guests with polar N—H bonds include amides, ureas and related sulfur compounds, substituted hydrazines, and aromatic amines.21-264,265 Complexes with these substrates exhibit a wide variety of stoichiometric and nonstoichiometric associations. A particularly popular association is the 1 2 guest host relationship as typified by the structure of the benzenesulfonamide complex with [18]crown-6 (84).266-267 The weak complexes formed between crown ethers and cryptands with certain proteins allow for solubilizing these species in organic solvents.268... 

Tri- and tetrazole aromatase inhibitors Mandelic amide Biaryl compounds Biaryl compounds Polycyclic aromatics Sulfur compounds Phosphorus compounds Nitrogen and cyano compounds... 

Acids Phosphoric acid, FFAP (carbowax-20m-terephthalic acid ester), trimer acid These modifiers will act as subtractive agents for basic components in the sample FFAP will selectively abstract aldehydes phosphoric acid may convert amides to the nitrile (of the same carbon number), desulfonate sulfur compounds, and may esterify or dehydrate alcohols... 

Re has recently come to the forefront in liquid phase oxidation catalysis, mainly as a result of the discovery of the catalytic properties of the alkyl compound CH3Re03 [methyltrioxorhenium (MTO)]. MTO forms mono-and diperoxo adducts with H2O2 these species are capable of transferring an oxygen atom to almost any nucleophile, including olefins, allylic alcohols, sulfur compounds, amides, and halide ions (9). Moreover, MTO catalysis can be accelerated by coordination of N ligands such as pyridine (379-381). An additional effect of such bases is that they buffer the strong Lewis acidity of MTO in aqueous solutions and therefore protect epoxides, for example. 

Hydrocarbons. Alcohols. Aldehydes. Ketones. Organic sulfur compounds. Hydrated compounds. Carbon acids. Carbon acid amides, urea, and other compounds... 

Adducts from acid amides and sulfur compounds... 

Oxidation of sulfur compounds. Aromatic amides are obtained from thio-amides on treatment with the H2O2-C0CI2 system. Aliphatic thioamides do not behave in the same way. 

Allylic sulfoxides and sulfones are completely metallated in liquid ammonia by all alkali amides [1]. For metallation in organic solvents, LDA and BuLi are usually applied. The lithiation of allyltrimethylsilane can be conveniently achieved with BuLi TMEDA (or HMPT) or f-BuLi TMEDA (or HMPT) in THF-alkane mixtures [3], As in the case of the sulfur compounds, extension of the unsaturated system leads to an increased acidity. Thus H2C=CHCH=CHCH2SiMe3 can be metallated with the less strongly basic LDA in THF [4], For the metallation of allylic selenides, LDA seems to be the reagent of choice. Butyllithium will presumably attack on selenium. 

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