American Health Foundation

Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595... 

Sugimura, T. Symposium on Environmental Aspects of Cancer The Role of Macro and Micro Components of Foods (abstract) American Health Foundation New York, 1982. 

Shimada T, McQueen CA, Williams GM. 1983. Study of effects on cultured liver cells of three chlorinated benzenes. Final Report. American Health Foundation. Report to Chemical Manufacturer Association. 

At the American Health Foundation, New York, NY, P. Foiles and S. Hecht, sponsored by the NCI, are attempting to develop sensitive immunoassays in mice for the detection of acrolein-DNA adducts in animals and eventually in humans exposed to the chemical. Dr. Foiles and his collaborators are pursuing P post-labeling methods for the detection of acrolein modified DNA. C. Sevilla, Proteins International, Rochester, MN, is attempting to develop monoclonal antibodies for acrolein-DNA adducts. These antibodies will be used in clinical and research monitoring of levels of the adduct in human DNA samples. 

Melikian, A.A. American Health Foundation Valhalla, NY Biological markers for tobacco smoke exposure to benzene NCI... 

Hoffmann, D. American Health Foundation Experimental tobacco carcinogenesis NCI... 

Most operational definitions of carcinogens include reference to animals as well as humans. As two eminent experts, Gary M. Williams and John H. Weisburger of the American Health Foundation, concisely put it ... 

Meisler JG, St. Jeor S. Summary and recommendations from the American Health Foundation s expert panel on healthy weight. Am J Clin Nutt 1996 63(3 Suppl) 474S 77S. 

The American Health Foundation is involved in on-going research to develop new organoselenium chemopreventive agents for cancer having an increased therapeutic ratio compared with some of the historical selenium compounds, such as selenite. Additional federally sponsored research that was reported in the CRIS/USDA (2001) and CRISP (2001) databases is shown in Table 3-8. 

El-Bayoumy, KE American Health Foundation Chemoprevention of oral cancer model studies CRISP 2001... 

Fiala, E American Health Foundation Organoselenium compounds as modifiers of carcinogenesis CRISP 2001... 

From E. L. Wynder, The Book of Health The American Health Foundation. 1981 Franklin Watts, Inc., New York. Used with permission. 

From Raymond Chang, Chemistry, 6th ed. Copyright 1998. The McGraw-Hill Companies, Inc., Dubuque, Iowa. All Rights Reserved. Reprinted by permission, p. 21 Caloric expenditure table This table has been reproduced from The Book of Health, E.L. lA nder, Editor. American Health Eoundation. New York, Franklin Watts, 1981, with permission of the American Health Foundation, p. 25. 

American Health Foundation, 33 The Dow Chemical Company, 43 ICI Central Toxicology Laboratoiy, 201 IIT Research Institute, 94 Jellinek, Schwartz, Connolly Freshman, Inc., 6... 

These and many other in-house reports on PAHs demonstrate that the early PAH research was not limited to academic or governmental laboratories or to laboratories at private institutions such as the Sloan-Kettering Institute, American Health Foundation, or Roswell Park Memorial Institute. Many of the tobacco industry reports on PAHs listed above may now be accessed at the Internet addresses cited in the references. 

Because they considered 1,2-benzenediol (catechol) a major constituent of tobacco smoke, a component they considered an important contributor to the biological properties of smoke, Hoffmann and his colleagues at the American Health Foundation conducted an extensive study in the early 1980s on the pyrosynthesis of 1,2-benzenediol (catechol) during the tobacco smoking process. The goal of the study was to determine the major precursor(s) in tobacco of the... 

A19 15A06 15A03 by Hoffmann and his American Health Foundation ... 

With the limiting analytical technology available in 1982, Lee et al. (2329) at the American Health Foundation reported that they were unable to measure significant quantities of 4-nitro-l,2-benzenediol (4-nitrocatechol) in cigarette MSS. El-Bayoumy et al. in a conference presentation (1122) and a journal publication (1124) reported that 1-nitronaphthalene,... 

Table XXHI-3 is a tabulation of the toxicants in tobacco and tobacco smoke from the lARC 1986 publication (1870) plus the seven lengthy publications co-authored from 1986 to 2001 by Hoffmann with his American Health Foundation colleagues. Examination of the various lists reveals several anomalies, none of which detracts from the meaningfulness of the publications. The anomalies include ...

Of the approximately 4800 substances in tobacco smoke (1373), 44 are beheved...to be relevant to tobacco-related diseases (23A06). These include... some volatile carbonyl compounds, tobacco-specific A-nitrosamines, aromatic amines, phenols, volatile alkenes, benzo[a]pyrene and metals. These substances are sometimes called colloquially Hoffmann analytes since similar lists of toxicological substances have been proposed by Dietrich Hoffmann et al. of the American Health Foundation in New York since the mid 1980s. The latest compilation by Hoffmann et al. lists 82 substances (1741,1743, 1744). 

The effects of 450 tobacco ingredients added to tobacco on the forty-four Hoffmann analytes in mainstream cigarette smoke have been determined...They are based on lists published by D. Hoffmann and co-workers of the American Health Foundation... 

The study has concentrated on the biologically active substances produced by pyrolysis, in particular the Hoffmann analytes. These analytes are believed by regulatory authorities in Canada and U.S.A. to be relevant to smoking-related diseases. They are based on lists published by Hoffmann and co-workers of the American Health Foundation in New York. For the pyrolysis of many of the non-volatile ingredients, no Hoffmann analytes were detected amongst the products. When they were occasionally formed, they included phenols, benzene, toluene, styrene and furfural (furfural is biologically active but it does not appear on any of the Hoffmann or regulatory authority lists). 

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