Altered genes

Guy, C.L., Niemi, K.J. Brambl, R. (1985). Altered gene expression during cold acclimation of spinach. Proceedings of the National Academy of Sciences, USA, 82, 3673-7. 

An alteration in the sequence of purine and pyrimidine bases in a gene due to a change—a removal or an insertion—of one or more bases may result in an altered gene product. Such alteration in the genetic material results in a mutation whose consequences are discussed in detail in Chapter 38. 

Intracellular steroid receptors, which alter gene expression, exist for corticosteroids, oestrogens and progesterone in the brain, as in the periphery but they cannot account for the relatively rapid depression of CNS function induced by some steroids. This was explained when Harrison and Simmonds (1984) discovered that alphaxalone (the steroid anaesthetic) potentiated the duration of GABA-induced currents at the GABAa receptor in slices of rat cuneate nucleus just like the barbiturates (Fig. 13.6). Of the... 

Jolkkonen, J, Jenner, P and Marsden, CD (1995) L-Dopa reverses altered gene expression of substance P but not enkephalin in the caudate-putamen of common marmosets treated with MPTP. Brain Res. Mol. Brain Res. 32 297-307. 

Liang P et al. Analysis of altered gene expression by differential display. Methods Enzymol 1995 254 304—321. 

Pennie WD. Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression. Toxicol Lett 2000 112-113 473-477. 

Kirsch T, Wellner M, Luft FC, Haller H, Li ppoldt A. Altered gene expression in cerebral capillaries of stroke-prone spontaneously hypertensive rats. Brain Res 2001 910 106-115. 

The other area is the use of microassays in toxicogenomic screening, early detection of the potential for compounds to alter gene expressions with adverse consequences (Pennie, 2000 Nuwaysir et al., 1999). 

This condition is inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder. 

Nicholson, J.K., Metabonomics, a generic platform for the investigation of drug toxicity, altered gene function and disease processes, Drug Discovery World, Summer, 23-28, 2004. 

Abstract Altered gene expression resulting from changes in the post-translational modification... 

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