Allergic conjunctivitis antihistamines

Levocabastine (Livostin) and olopatadine (Patanol) are ophthalmic antihistamines that can be used for allergic conjunctivitis that is often associated with allergic rhinitis. However, systemic antihistamines are usually effective for allergic conjunctivitis, making an ocular product unnecessary. They may be a logical addition to nasal glucocorticoids when ocular symptoms occur. 

Hj antihistamines are clinically used in the treatment of histamine-mediated allergic conditions. Specifically, these indications may include allergic rhinitis, allergic conjunctivitis, allergic dermatological conditions (contact dermatitis), pruritus (atopic dermatitis, insect... 

Epinastine (Elestat) [Antihistamine] Uses Itching w/ allergic conjunctivitis Action Antihistamine Dose 1 gtt bid Caution [C, /-] Disp Soln SE Burning, folliculosis, hyperemia, pruritus, URI, HA, rhinitis, sinusitis, cough, pharyngitis EMS None OD Unlikely... 

Olopatadine (Patanol) [Ophthalmic Antihistamine] Uses Allergic conjunctivitis Action Hj-rec tor antagonist Dose 1—2 gtt in eye(s) bid allow 6—8 h between doses Caution [C, ] Disp Sohi SE Local irritation, HA, rhinitis EMS None OD Unlikely... 

Mechanism of Action An antihistamine that competes with histamine for histamine receptor sites on cells in the blood vessels, G1 tract, and respiratory tract. Therapeutic Effect Relieves symptoms associated with seasonal allergic rhinitis, such as increased mucus production and sneezing and symptoms associated with allergic conjunctivitis, such as redness, itching, and excessive tearing. 

Azelastine hydrochloride an antihistamine which is used for allergic reactions such as hay fever and allergic conjunctivitis. 

In moderate to severe cases of allergic conjunctivitis, treatment considerations also include mast cell stabilizers, antihistamine-mast cell stabilizer combinations, oral antihistamines, NSAIDs, and, in severe cases, topical steroids. 

Emedastine is a potent second-generation antihistamine with proven efficacy in allergic conjunctivitis (1). 

Antihistamines Antazoline sulphate Otrivine-Antistin Allergic conjunctivitis... 

Allergic conjunctivitis, often associated with allergic rhinitis, can be treated with an ophthalmic antihistamine such as levocabas-tine. Since systemic antihistamines usually are also effective for allergic conjunctivitis, levocabastine is a logical addition to nasal steroids when ocular symptoms occur, and is an acceptable approach in patients whose only symptoms involve the eyes. 

Azelastine is an ophthalmic antihistaminic preparation. It is indicated in the treatment of symptoms of seasonal allergic rhinitis, such as rhinorrhea, sneezing, and nasal pruritus treatment of symptoms of vasomotor rhinitis, such as rhin-orrhea, nasal congestion, and postnasal drip (nasal inhalation) treatment of itching of eye associated with allergic conjunctivitis (ophthalmic). 

Diphenhydramine is an Hj-antihistaminic agent with anticholinergic and sedative properties. Diphenhydramine (25 to 50 mg t.i.d.) is indicated in allergic conjunctivitis, urticaria, and angioedema resulting from food, blood, or plasma in combination with epinephrine in anaphylactic... 

The most common symptoms of allergic conjunctivitis treated by ophthalmologists include ocular pruritis, erythema, edema, and tearing. The traditional drugs of choice to treat these symptoms of allergic conjunctivitis have been antihistamines alone or in combination with vasoconstrictors. Antihistamines currently employed in this area as topical solutions include pheniramine, antazoline, pyrilamine, and levocabastine. However, these drugs have some disadvantages such as low potency (antazoline), slow... 

Ketotifen is an ophthalmic antihistamine that inhibits release of mediators from cells involved in hypersensitivity reactions. It is indicated in temporary prevention of itching of eyes caused by allergic conjunctivitis. 

Epinastine is a potent, iong-acting Hi antihistamine and an inhibitor of the release of histamine and other transmitters from mast ceiis. it has some affinity for H2 receptors as well. It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is classified as a nonsedating antihistamine. 

Bieiory L, Lien KW, Bigelsen S. Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis. Drugs 2005 65 215-228. 

Antihistaminics are widely used in the palliative treatment in allergic conditions like hay fever, urticaria, some forms of pruritus, rhinitis, conjunctivitis, nasal discharge, mild asthma etc. A few antihistaminics possess potent antiemetic action and hence are frequently employed in the prevention and treatment of irradiation sickness, motion sickness (air, sea, road), nausea in pregnancy and postoperative vomiting. 

Therapeutic profile The drug is a second-generation antihistamine, lacking sedative activity, for the treatment of allergic diseases, including allergic rhino-conjunctivitis, seasonal allergic rhinitis, urticaria and atopic dermatitis. 

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