Ascaris allergens

Christie, J.F., Dunbar, B., Davidson, I. and Kennedy, M.W. (1990) N-terminal amino acid sequence identity between a major allergen of Ascaris lumbricoides and Ascaris suum, and MHC-restricted IgE responses to it. Immunology 69, 596-602. 

Kennedy, M.W., Brass, A., McCruden, A.B., Price, N.C., Kelly, S.M. and Cooper, A. (1995b) The ABA-1 allergen of the parasitic nematode Ascaris suum fatty acid and retinoid binding function and structural characterization. Biochemistry 34, 6700-6710. 

Tomlinson, L.A., Christie, J.F., Fraser, E.M., Mclaughlin, D., Mcintosh, A.E. and Kennedy, M.W. (1989) MHC restriction of the antibody repertoire to secretory antigens, and a major allergen, of the nematode parasite Ascaris. Journal of Immunology 143, 2349-2356. 

Anti-allergenic activity. Hot water extract of the of the dried rhizome, administered by gastric intubation to mice at a dose of 100 mg/kg, was inactive vs type IV reaction with contact dermatitis induced by picryl chloride and type I reaction induced by antidinitrophenylated ascaris-IgE serum in 48 hours homologous PCA in rats. Dosing... 

Lodoxamlde tromethmlne (U-42585E, 1 ) is 2500 X more potent than DSCG in the rat PCA test 3 administered l.v., and is orally active in ascaris sensitive monkeys at 5 mg/fcg. in clinical studies, 12. appears to protect extrinsic asthmatics from allergen Induced bronchoconstrictio administered by the aerosol route, and 5 of lO asthmatic patients were protected by lodoxamlde given orally at doses of 1 and 2 mg. 

Oxatomide has been selected from a new chemical series of benzimidazolones and benzimidazoles on the basis of its activity on hypersensitivity and histamine-induced reactions in three species, the guinea-pig, the rat and the dog. In a well-known model, the guinea-pig anaphylaxis, oxatomide was at least as effective on the anaphylactic shock as on the histamine oedema induced in the same animals. In the rat, the new compound was an orally active inhibitor of PCA-reactions. Compound 48/80-induced lethal shock was prevented at doses of the same order as those required to inhibit histamine skin reactions. In the dog inhibition of allergic reactions, induced by Ascaris allergens in the skin of hypersensitive dogs, inhibition of histamine skin reactions and reduction of circulating histamine released by Cremophor EL were obtained by virtually the same oral doses. 

Ascaris lumbricoides and Necator Low risk of sensitization to dust mite allergen 9... 

Sheep have also been utilized as a model for human asthma with the primary inciting allergen being inoculation with Ascaris suum. As is the case with dogs and humans, there is considerable variability between sheep with the degree of response to allergen exposure. While a potential useful model, the size and cost of the animals may be a challenge. 

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